Homo sapiens Gene: CCL17
Summary
InnateDB Gene IDBG-107891.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol CCL17
Gene Name C-C motif chemokine ligand 17
Synonyms A-152E5.3; ABCD-2; SCYA17; TARC;
Species Homo sapiens
Ensembl Gene ENSG00000102970
Encoded Proteins
C-C motif chemokine ligand 17
C-C motif chemokine ligand 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL4 (Interleukin-4) induces CCL17 expression via two STAT6 motifs in the proximal promoter and a distal tandem STAT6 element
CCL17 is required for the induction of intestinal inflammation in mice. CCL17 has an autocrine effect on dendritic cells that promotes production of inflammatory cytokines and activation of Th1 and Th17 cells and reduces expansion of Treg cells. (Demonstrated in mice)
Entrez Gene
Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57404767-57416062
Strand Forward strand
Band q21
Transcripts
ENST00000219244 ENSP00000219244
ENST00000616880 ENSP00000480147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0008009 chemokine activity
GO:0031729 CCR4 chemokine receptor binding
GO:0048020 CCR chemokine receptor binding
Biological Process
GO:0002548 monocyte chemotaxis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0010469 regulation of receptor activity
GO:0030593 neutrophil chemotaxis
GO:0043547 positive regulation of GTPase activity
GO:0045662 negative regulation of myoblast differentiation
GO:0048247 lymphocyte chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
C-type lectin receptor signaling pathway pathway
IL-17 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
IL4-mediated signaling events
Cross-References
SwissProt Q92583
TrEMBL
UniProt Splice Variant
Entrez Gene 6361
UniGene
RefSeq NM_002987 XM_011523256 XM_017023530
HUGO HGNC:10615
OMIM 601520
CCDS CCDS10780
HPRD
IMGT
EMBL AC004382 BC069107 BC112066 BC112068 CH471092 D43767 EF064767
GenPept AAC24308 AAH69107 AAI12067 AAI12069 ABK41950 BAA07824 EAW82921
RNA Seq Atlas 6361