Homo sapiens Gene: NOD1
Summary
InnateDB Gene IDBG-11085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOD1
Gene Name nucleotide-binding oligomerization domain containing 1
Synonyms CARD4; CLR7.1; NLRC1;
Species Homo sapiens
Ensembl Gene ENSG00000106100
Encoded Proteins
nucleotide-binding oligomerization domain containing 1
nucleotide-binding oligomerization domain containing 1
nucleotide-binding oligomerization domain containing 1
nucleotide-binding oligomerization domain containing 1
nucleotide-binding oligomerization domain containing 1
nucleotide-binding oligomerization domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NOD1 and NOD2 represent central players in the control of the immune responses to bacterial infections and inflammation.
NOD1 and NOD2 can induce CCL5 (RANTES) through NF-kappaB pathway, orchestrating the global Nod-dependent immune defence during bacterial infections.
NOD1 and NOD2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
NOD1 plays an important role in host defence against bacterial infection by regulating direct killing of Helicobacter pylori bacteria by antimicrobial peptides.
NOD1-dependent responses account for host resistance against T. cruzi infection by mechanisms independent of cytokine production.
NOD1 plays a role in priming innate defences, facilitating a rapid response to infection by recognizing peptidoglycan from microbiota and enhancing killing of pathogens by bone marrow-derived neutrophils.
NOD1 is a peripheral peptidoglycan intracellular sensor and is important for the progression and pathogenesis of experimental autoimmune encephalomyelitis (animal model of multiple sclerosis).
NOD1 detects heat-killed Legionella pneumophila and stimulates NFkB and IFN-beta promoter activity. NOD1 deficiency results in impaired bacterial clearance and increased proinflammatory cytokine at 24hrs post-infection. (Demonstrated in murine model)
NOD1 is expressed by trophoblast cells across gestation and may have a role in mediating infection-associated inflammation and prematurity. Activation of NOD1 by bacterial peptidoglycan-derived peptide induces maternal-fetal inflammation and preterm labour.
Nod1 KO mice were protected from high-fat diet induced inflammation, lipid accumulation, and peripheral insulin intolerance. Ex vivo, NOD1 activation by bacterial peptidoglycan mimetics induces proinflammatory cytokine secretion and impaired insulin-stimulated glucose uptake in adipocytes. Hence, NOD1 is a plausible, new link between innate immunity and metabolism. (Demonstrated in murine model)
Helicobacter pylori infection of gastric epithelial cells activates NOD1 to enhance IFN-gamma signalling.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nod1 and Nod2 activation results in substantial secretion of Ccl5 by murine macrophages and induces binding of NF-kappaB subunits to Ccl5 promoter.
[Mus musculus] Nod1 can activate the ISGF3 signaling pathway that is usually associated with protection against viral infection to provide mice with robust type I IFN-mediated protection from H. pylori and possibly other mucosal infections.
[Mus musculus] Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila.
[Mus musculus] Nod1 and Nod2 can detect Legionella pneumophila and these receptors modulate the in vivo pulmonary immune response differently.
[Mus musculus] Nod1 is a peripheral peptidoglycan intracellular sensor and is important for the progression and pathogenesis of experimental autoimmune encephalomyelitis (animal model of multiple sclerosis).
[Mus musculus] Nod1 detects heat-killed Legionella pneumophila and stimulates NFkB and IFN-beta promoter activity. Nod1 deficiency results in impaired bacterial clearance and increased proinflammatory cytokine at 24hrs post-infection.
[Mus musculus] Nod1 is expressed by trophoblast cells across gestation and may have a role in mediating infection-associated inflammation and prematurity. Activation of Nod1 by bacterial peptidoglycan-derived peptide induces maternal-fetal inflammation and preterm labour.
[Mus musculus] Nod1 KO mice were protected from high-fat diet induced inflammation, lipid accumulation, and peripheral insulin intolerance. Ex vivo, Nod1 activation by bacterial peptidoglycan mimetics induces proinflammatory cytokine secretion and impaired insulin-stimulated glucose uptake in adipocytes. Hence, Nod1 is a plausible, new link between innate immunity and metabolism.
[Mus musculus] Nod1 and Nod2 synergize with Tlr4 in dendritic cells to increase IL12 production and enhance invariant natural killer T (iNKT) cell activation, and are important regulators of the IFN gamma response by iNKT cells during S. typhimurium and L. monocytogenes infections.
[Mus musculus] Salmonella enterica serovar Typhimurium ?msbB that possesses a modified lipid A triggers exacerbated colitis in the absence of Nod1 and/or Nod2, which is likely due to increased Tlr2 stimulation.
Entrez Gene
Summary This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5\' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30424527-30478784
Strand Reverse strand
Band p14.3
Transcripts
ENST00000222823 ENSP00000222823
ENST00000434755 ENSP00000416946
ENST00000419799 ENSP00000395551
ENST00000411552 ENSP00000396046
ENST00000413433 ENSP00000399505
ENST00000419601 ENSP00000410917
ENST00000489614
ENST00000467706
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 54 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042834 peptidoglycan binding
GO:0050700 CARD domain binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0009595 detection of biotic stimulus
GO:0016045 detection of bacterium
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035556 intracellular signal transduction
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042228 interleukin-8 biosynthetic process
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0046330 positive regulation of JNK cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0051403 stress-activated MAPK cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
MAP kinase activation in TLR cascade pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
NOD1/2 Signaling Pathway pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
activated TAK1 mediates p38 MAPK activation pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
NOD-like receptor signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.405153 Hs.713018 Hs.738731
RefSeq NM_006092 XM_005249568 XM_005249572 XM_005249576 XM_006715633 XM_006715634 XM_006715636 XM_006715637
HUGO
OMIM
CCDS CCDS5427
HPRD 05815
IMGT
EMBL
GenPept
RNA Seq Atlas