Homo sapiens Gene: AGFG1
Summary
InnateDB Gene IDBG-118731.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol AGFG1
Gene Name ArfGAP with FG repeats 1
Synonyms HRB; RAB; RIP;
Species Homo sapiens
Ensembl Gene ENSG00000173744
Encoded Proteins
ArfGAP with FG repeats 1
ArfGAP with FG repeats 1
ArfGAP with FG repeats 1
ArfGAP with FG repeats 1
ArfGAP with FG repeats 1
ArfGAP with FG repeats 1
ArfGAP with FG repeats 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:227472152-227561214
Strand Forward strand
Band q36.3
Transcripts
ENST00000310078 ENSP00000312059
ENST00000373671 ENSP00000362775
ENST00000409171 ENSP00000387218
ENST00000409315 ENSP00000387154
ENST00000409979 ENSP00000387282
ENST00000456594 ENSP00000405429
ENST00000458212 ENSP00000396469
ENST00000486932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001675 acrosome assembly
GO:0006406 mRNA export from nucleus
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007289 spermatid nucleus differentiation
GO:0030154 cell differentiation
GO:0043547 positive regulation of GTPase activity
GO:0045109 intermediate filament organization
GO:0051028 mRNA transport
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005829 cytosol
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Cargo recognition for clathrin-mediated endocytosis pathway
Clathrin-mediated endocytosis pathway
Vesicle-mediated transport pathway
Membrane Trafficking pathway
KEGG
Influenza A pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001135187 NM_001135188 NM_001135189 NM_004504 XM_005246516 XM_006712478 XM_006712479 XM_006712480
HUGO
OMIM
CCDS CCDS2467 CCDS46533 CCDS46534 CCDS46535
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas