Mus musculus Gene: C5ar1
Summary
InnateDB Gene IDBG-146297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C5ar1
Gene Name complement component 5a receptor 1
Synonyms C5aR; C5r1; Cd88; D7Msu1;
Species Mus musculus
Ensembl Gene ENSMUSG00000049130
Encoded Proteins
complement component 5a receptor 1
complement component 5a receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] C5AR1 engage in crosstalk with TLR2 and Porphyromonas gingivalis, a major oral and systemic pathogen with complement C5 convertase-like activity, synergizes with C5a (fragment of complement protein C5) to increase cyclic adenosine monophosphate (cAMP) concentrations, resulting in suppression of macrophage immune function and enhanced pathogen survival.
[Homo sapiens] C5AR1 is a receptor for C5a, a chief component of complement activation produced via all three complement pathways (i.e., lectin, classical, and alternative), stimulated tissue-resident macrophages, but not dendritic cells, to produce inflammatory cytokines including IL-6, in synergy with Toll-like receptor signalling or, notably, granulocyte/macrophage colony-stimulating factor (GM-CSF).
[Homo sapiens] Increasing circulating C5AR1 serum concentration, coupled with decreased C5AR1 expression on neutrophils is correlated with lethality from septic shock.
[Homo sapiens] Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197405:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16246743-16259540
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000050770 ENSMUSP00000060003
ENSMUST00000168818 ENSMUSP00000129972
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001856 complement component C5a binding
GO:0004878 complement component C5a receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004944 C5a anaphylatoxin receptor activity
Biological Process
GO:0002430 complement receptor mediated signaling pathway
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0021534 cell proliferation in hindbrain
GO:0030593 neutrophil chemotaxis
GO:0031100 organ regeneration
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0038178 complement component C5a signaling pathway
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050830 defense response to Gram-positive bacterium
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Neuroactive ligand-receptor interaction pathway
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.247623 Mm.416136
RefSeq NM_001173550 NM_007577
OMIM
CCDS CCDS20846
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas