Mus musculus Gene: Il25
Summary
InnateDB Gene IDBG-162540.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il25
Gene Name interleukin 25
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040770
Encoded Proteins
interleukin 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL25, a member of the IL17 cytokine family, promotes the accumulation of a lineage-negative multipotent progenitor (MPP) cell population in the gut-associated lymphoid tissue that promotes T(H)2 cytokine responses, presenting an innate immune pathway that promotes T(H)2 cytokine responses at mucosal sites.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166090:
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:54932695-54935837
Strand Forward strand
Band C2
Transcripts
ENSMUST00000037863 ENSMUSP00000039641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0030380 interleukin-17E receptor binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0006954 inflammatory response
GO:0009620 response to fungus
GO:0009624 response to nematode
GO:0030222 eosinophil differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q8VHH8
UniProt Splice Variant
Entrez Gene 140806
UniGene Mm.90154
RefSeq NM_080729 XM_006518544 XM_006518545
OMIM
CCDS CCDS36926
HPRD
IMGT
MGI ID MGI:2155888
MGI Symbol Il25
EMBL AF458060 BC120568 BC125524 BC144962 CT025533
GenPept AAI20569 AAI25525 AAI44963 AAL57623
RNA Seq Atlas 140806