Mus musculus Gene: Hc
Summary
InnateDB Gene IDBG-163835.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hc
Gene Name hemolytic complement
Synonyms C5; C5a; He;
Species Mus musculus
Ensembl Gene ENSMUSG00000026874
Encoded Proteins
hemolytic complement
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains, C5a is a complement anaphylatoxin that can stimulate the generation of nitric oxide along with the secretion of histamine and leukotriene LTC4 from several cell types and can bring about an increase in vascular permeability that facilitates eosinophil accumulation at sites of allergic inflammation.
[Homo sapiens] C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains. C5b first associates with complement component 6 (C6), which in turn initiates the assembly of the cytolytic membrane attack complex (MAC).
[Homo sapiens] C5 fragments are released from neutrophils upon their activation of the alternative complement pathway and this further amplifies neutrophil pro-inflammatory responses.
[Homo sapiens] C5 (C5a) is a critical mediator in blood during Candida albicans infection.
[Homo sapiens] Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106804:
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:34983331-35061438
Strand Reverse strand
Band B
Transcripts
ENSMUST00000028233 ENSMUSP00000028233
ENSMUST00000156412
ENSMUST00000156049
ENSMUST00000125549
ENSMUST00000151628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0031714 C5a anaphylatoxin chemotactic receptor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0002523 leukocyte migration involved in inflammatory response
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010700 negative regulation of norepinephrine secretion
GO:0010760 negative regulation of macrophage chemotaxis
GO:0010951 negative regulation of endopeptidase activity
GO:0019835 cytolysis
GO:0033602 negative regulation of dopamine secretion
GO:0042593 glucose homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0050921 positive regulation of chemotaxis
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
GPCR downstream signaling pathway
Complement cascade pathway
Regulation of Complement cascade pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Immune System pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Terminal pathway of complement pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
Activation of C3 and C5 pathway
KEGG
Complement and coagulation cascades pathway
Prion diseases pathway
Staphylococcus aureus infection pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Innate Immune System pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Immune System pathway
Activation of C3 and C5 pathway
Regulation of Complement cascade pathway
Complement cascade pathway
GPCR ligand binding pathway
Terminal pathway of complement pathway
KEGG
Complement and coagulation cascades pathway
Prion diseases pathway
Staphylococcus aureus infection pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
Alternative complement pathway [Biocarta view]
Classical complement pathway [Biocarta view]
Lectin induced complement pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2168
RefSeq NM_010406
OMIM
CCDS CCDS15957
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas