Mus musculus Gene: Clock
Summary
InnateDB Gene IDBG-172856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clock
Gene Name circadian locomotor output cycles kaput
Synonyms 5330400M04Rik; bHLHe8; KAT13D; mKIAA0334;
Species Mus musculus
Ensembl Gene ENSMUSG00000029238
Encoded Proteins
circadian locomotor output cycles kaput
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76212177-76304548
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000075159 ENSMUSP00000074656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 47 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0016573 histone acetylation
GO:0032922 circadian regulation of gene expression
GO:0042634 regulation of hair cycle
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050796 regulation of insulin secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051775 response to redox state
GO:0071479 cellular response to ionizing radiation
GO:2000074 regulation of type B pancreatic cell development
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033391 chromatoid body
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mus musculus biological processes pathway
Chromatin organization pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Circadian Clock pathway
Circadian Clock pathway
REV-ERBA represses gene expression pathway
RORA activates circadian gene expression pathway
HATs acetylate histones pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Chromatin modifying enzymes pathway
PPARA activates gene expression pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Bmal1:Clock,Npas2 activates circadian gene expression pathway
KEGG
Circadian rhythm pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
HATs acetylate histones pathway
Circadian Clock pathway
Metabolism of lipids and lipoproteins pathway
REV-ERBA represses gene expression pathway
PPARA activates gene expression pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
RORA activates circadian gene expression pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Circadian rhythm pathway
INOH
PID BIOCARTA
PID NCI
Circadian rhythm pathway
Cross-References
SwissProt O08785
TrEMBL Q6ZQD6 Q8C9W6
UniProt Splice Variant
Entrez Gene 12753
UniGene Mm.3552 Mm.470874
RefSeq NM_001289826 NM_007715 XM_006534741 XM_006534742 XM_006534743 XM_006534744 XM_006534745 XM_006534747
OMIM
CCDS CCDS19360
HPRD
IMGT
MGI ID MGI:99698
MGI Symbol Clock
EMBL AF000998 AF146793 AK040337 AK129118
GenPept AAC53200 AAD30565 BAC30568 BAC97928
RNA Seq Atlas 12753