Homo sapiens Gene: YWHAG
Summary
InnateDB Gene IDBG-23145.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAG
Gene Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Synonyms 14-3-3GAMMA; PPP1R170;
Species Homo sapiens
Ensembl Gene ENSG00000170027
Encoded Proteins
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:76326794-76359031
Strand Reverse strand
Band q11.23
Transcripts
ENST00000307630 ENSP00000306330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 347 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 347 [view]
Protein-Protein 345 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0008426 protein kinase C inhibitor activity
GO:0019904 protein domain specific binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006469 negative regulation of protein kinase activity
GO:0006605 protein targeting
GO:0006915 apoptotic process
GO:0009966 regulation of signal transduction
GO:0045664 regulation of neuron differentiation
GO:0048167 regulation of synaptic plasticity
GO:0061024 membrane organization
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
Prolactin pathway
REACTOME
Loss of Nlp from mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Apoptosis pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
Centrosome maturation pathway
G2/M Transition pathway
Translocation of GLUT4 to the plasma membrane pathway
Cell Cycle, Mitotic pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Intrinsic Pathway for Apoptosis pathway
Mitotic G2-G2/M phases pathway
Activation of BAD and translocation to mitochondria pathway
Membrane Trafficking pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
INOH
Fas signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
IL3-mediated signaling events
Cross-References
SwissProt P61981
TrEMBL B4DHC4
UniProt Splice Variant
Entrez Gene 7532
UniGene Hs.592470 Hs.706016
RefSeq NM_012479
HUGO HGNC:12852
OMIM 605356
CCDS CCDS5584
HPRD 05639
IMGT
EMBL AB024334 AC006388 AF142498 AK295029 BC020963 CR541904 CR541925
GenPept AAD48408 AAH20963 BAA85184 BAG58085 CAG46702 CAG46723
RNA Seq Atlas 7532