Homo sapiens Gene: ACAA1
Summary
InnateDB Gene IDBG-25581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAA1
Gene Name acetyl-CoA acyltransferase 1
Synonyms ACAA; PTHIO; THIO;
Species Homo sapiens
Ensembl Gene ENSG00000060971
Encoded Proteins
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
acetyl-CoA acyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:38103129-38137242
Strand Reverse strand
Band p22.2
Transcripts
ENST00000333167 ENSP00000333664
ENST00000301810 ENSP00000301810
ENST00000411549 ENSP00000414021
ENST00000450296 ENSP00000395183
ENST00000452171 ENSP00000391078
ENST00000421218 ENSP00000398172
ENST00000440176 ENSP00000389226
ENST00000423611 ENSP00000396485
ENST00000447223 ENSP00000405785
ENST00000418880 ENSP00000403124
ENST00000469559
ENST00000480865
ENST00000469600
ENST00000465181
ENST00000484284
ENST00000460424
ENST00000489559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0005515 protein binding
GO:0016401 palmitoyl-CoA oxidase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0008206 bile acid metabolic process
GO:0008610 lipid biosynthetic process
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559 unsaturated fatty acid metabolic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
alpha-linolenic acid (ALA) metabolism pathway
Peroxisomal lipid metabolism pathway
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
Beta-oxidation of very long chain fatty acids pathway
Metabolism pathway
KEGG
Fatty acid degradation pathway
Valine, leucine and isoleucine degradation pathway
alpha-Linolenic acid metabolism pathway
Biosynthesis of unsaturated fatty acids pathway
PPAR signaling pathway pathway
Peroxisome pathway
INOH
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F2Z2Q6
UniProt Splice Variant
Entrez Gene 30
UniGene Hs.643487
RefSeq NM_001130410 NM_001607 XM_006713122
HUGO HGNC:82
OMIM 604054
CCDS CCDS2673 CCDS46794
HPRD 06815
IMGT
EMBL AP006309
GenPept
RNA Seq Atlas 30