Homo sapiens Gene: TP53
Summary
InnateDB Gene IDBG-26364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TP53
Gene Name tumor protein p53
Synonyms BCC7; LFS1; P53; TRP53;
Species Homo sapiens
Ensembl Gene ENSG00000141510
Encoded Proteins
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
tumor protein p53
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TP53 binds to canonical and non-canonical promoter regions of the human TLR gene family and up-regulates the expression of TLRs. The activation of TP53 can directly influence the TLR-mediated induction of cytokines.
TP53 serves as a host antiviral factor and enhances both the innate and adaptive immune responses to influenza A virus. (Demonstrated in mice)
Coronavirus engages papain-like proteases to escape from the innate antiviral response of the host by inhibiting TP53-IRF7-IFNB1 signalling.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tpr53 serves as a host antiviral factor and enhances both the innate and adaptive immune responses to influenza A virus.
Entrez Gene
Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7661779-7687550
Strand Reverse strand
Band p13.1
Transcripts
ENST00000269305 ENSP00000269305
ENST00000359597 ENSP00000352610
ENST00000413465 ENSP00000410739
ENST00000420246 ENSP00000391127
ENST00000455263 ENSP00000398846
ENST00000445888 ENSP00000391478
ENST00000504290 ENSP00000484409
ENST00000510385 ENSP00000478499
ENST00000504937 ENSP00000481179
ENST00000509690 ENSP00000425104
ENST00000514944 ENSP00000423862
ENST00000505014
ENST00000508793 ENSP00000424104
ENST00000503591 ENSP00000426252
ENST00000576024 ENSP00000458393
ENST00000574684
ENST00000619186 ENSP00000484375
ENST00000618944 ENSP00000481401
ENST00000610623 ENSP00000477531
ENST00000610292 ENSP00000478219
ENST00000620739 ENSP00000481638
ENST00000622645 ENSP00000482222
ENST00000610538 ENSP00000480868
ENST00000619485 ENSP00000482537
ENST00000604348 ENSP00000473895
ENST00000617185 ENSP00000482258
ENST00000615910 ENSP00000482903
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1328 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.
Experimentally validated
Total 1328 [view]
Protein-Protein 1244 [view]
Protein-DNA 66 [view]
Protein-RNA 0
DNA-DNA 18 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 85 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030971 receptor tyrosine kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035033 histone deacetylase regulator activity
GO:0035035 histone acetyltransferase binding
GO:0042802 identical protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0051087 chaperone binding
GO:0051721 protein phosphatase 2A binding
GO:0097371 MDM2/MDM4 family protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000733 DNA strand renaturation
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001836 release of cytochrome c from mitochondria
GO:0002309 T cell proliferation involved in immune response
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002931 response to ischemia
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006979 response to oxidative stress
GO:0006983 ER overload response
GO:0007049 cell cycle
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007275 multicellular organismal development
GO:0007369 gastrulation
GO:0007406 negative regulation of neuroblast proliferation
GO:0007417 central nervous system development
GO:0007569 cell aging
GO:0007596 blood coagulation
GO:0008104 protein localization
GO:0008156 negative regulation of DNA replication
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008340 determination of adult lifespan
GO:0009303 rRNA transcription
GO:0009411 response to UV
GO:0009651 response to salt stress
GO:0009792 embryo development ending in birth or egg hatching
GO:0010165 response to X-ray
GO:0010332 response to gamma radiation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016032 viral process
GO:0021549 cerebellum development
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031065 positive regulation of histone deacetylation
GO:0031497 chromatin assembly
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032461 positive regulation of protein oligomerization
GO:0033077 T cell differentiation in thymus
GO:0034103 regulation of tissue remodeling
GO:0034613 cellular protein localization
GO:0034644 cellular response to UV
GO:0035264 multicellular organism growth
GO:0035690 cellular response to drug
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0042127 regulation of cell proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046677 response to antibiotic
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048147 negative regulation of fibroblast proliferation
GO:0048568 embryonic organ development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051097 negative regulation of helicase activity
GO:0051262 protein tetramerization
GO:0051276 chromosome organization
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0070243 regulation of thymocyte apoptotic process
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0070266 necroptotic process
GO:0071158 positive regulation of cell cycle arrest
GO:0071456 cellular response to hypoxia
GO:0071479 cellular response to ionizing radiation
GO:0071850 mitotic cell cycle arrest
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090343 positive regulation of cell aging
GO:0090399 replicative senescence
GO:0090403 oxidative stress-induced premature senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097252 oligodendrocyte apoptotic process
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901525 negative regulation of macromitophagy
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005669 transcription factor TFIID complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0016605 PML body
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
Oncostatin_M pathway
REACTOME
p53-Dependent G1/S DNA damage checkpoint pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Activation of NOXA and translocation to mitochondria pathway
Pre-NOTCH Expression and Processing pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Stabilization of p53 pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Activation of PUMA and translocation to mitochondria pathway
Apoptosis pathway
Signal Transduction pathway
Cell Cycle pathway
Pre-NOTCH Transcription and Translation pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Transcriptional activation of p53 responsive genes pathway
Activation of BH3-only proteins pathway
p53-Dependent G1 DNA Damage Response pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
Transcriptional activation of cell cycle inhibitor p21 pathway
Factors involved in megakaryocyte development and platelet production pathway
Intrinsic Pathway for Apoptosis pathway
G1/S DNA Damage Checkpoints pathway
Oxidative Stress Induced Senescence pathway
Hemostasis pathway
Cell Cycle Checkpoints pathway
KEGG
MAPK signaling pathway pathway
Cell cycle pathway
p53 signaling pathway pathway
Apoptosis pathway
Wnt signaling pathway pathway
Neurotrophin signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Huntington's disease pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Basal cell carcinoma pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
PID BIOCARTA
Atm signaling pathway [Biocarta view]
Regulation of transcriptional activity by pml [Biocarta view]
Rb tumor suppressor/checkpoint signaling in response to dna damage [Biocarta view]
Chaperones modulate interferon signaling pathway [Biocarta view]
Cell cycle: g1/s check point [Biocarta view]
Cell cycle: g2/m checkpoint [Biocarta view]
Overview of telomerase protein component gene htert transcriptional regulation [Biocarta view]
Telomeres telomerase cellular aging and immortality [Biocarta view]
Double stranded rna induced gene expression [Biocarta view]
Estrogen responsive protein efp controls cell cycle and breast tumors growth [Biocarta view]
Apoptotic signaling in response to dna damage [Biocarta view]
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
Hypoxia and p53 in the cardiovascular system [Biocarta view]
Regulation of cell cycle progression by plk3 [Biocarta view]
Role of brca1 brca2 and atr in cancer susceptibility [Biocarta view]
P53 signaling pathway [Biocarta view]
Btg family proteins and cell cycle regulation [Biocarta view]
PID NCI
PLK3 signaling events
Aurora A signaling
Direct p53 effectors
Validated targets of C-MYC transcriptional activation
LKB1 signaling events
p53 pathway
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
p75(NTR)-mediated signaling
Signaling events mediated by HDAC Class III
Signaling mediated by p38-alpha and p38-beta
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
BARD1 signaling events
Cross-References
SwissProt
TrEMBL G4Y083 L0ES54 Q0PKT5 Q6IT77 S4R334
UniProt Splice Variant
Entrez Gene 7157
UniGene
RefSeq NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 NM_001126118 NM_001276695 NM_001276696 NM_001276697 NM_001276698 NM_001276699 NM_001276760 NM_001276761
HUGO HGNC:11998
OMIM 191170
CCDS CCDS11118 CCDS45605 CCDS45606 CCDS73963 CCDS73964 CCDS73965 CCDS73966 CCDS73967 CCDS73968 CCDS73969 CCDS73970 CCDS73971
HPRD
IMGT
EMBL AC007421 AC087388 AY627884 DQ812984 JF923567 JQ751923 JQ751928 JQ751931 JQ751933 JQ751934 JQ751936 JQ751938 JQ751939 JQ751941 JQ751947 JQ751948 JQ751952 JQ751957 JQ751958 JQ751959 JQ751961 JQ751965 JQ751966 JQ751971 JQ751972 JQ751975 JQ751979 JQ751988 JQ751993 JQ751994 JQ752001 JQ752012 JQ752017 JQ752018 JQ752019 JQ752021 JQ752023 JQ752026 JQ752027 JQ752030 JQ752033 JQ752034 JQ752035 JQ752046 JQ752047 JQ752063 JQ752064 JQ752072 JQ752073 JQ752086 JQ752087 JQ752088 JQ752089 JQ752094 JQ752096 JQ752097 JQ752098 JQ752103 JQ752104 JQ752105 JQ752106 JQ752117 JQ752118 JQ752119 JQ752120 JQ752123 JQ752124 JQ752125 JQ752126 JQ752131 JQ752137 JQ752138 JQ752139 JQ752142 JQ752144 JQ752147 JQ752154 JQ752156 JQ752162 JQ752164 JQ752171 JQ752174 JQ752179 JQ752184 JQ752186 JQ752191 JQ752194 JQ752200 JQ752202 JQ752204 JQ752205 JQ752208 JQ752209 JQ752210 JQ752211 JQ752212 JQ752216 JQ752219 JQ752220 JQ752224 JQ752226 JQ752227 JQ752231 JQ752232
GenPept AAT40418 ABG67755 AEQ16481 AGA63129 AGA63134 AGA63137 AGA63139 AGA63140 AGA63142 AGA63144 AGA63145 AGA63147 AGA63153 AGA63154 AGA63158 AGA63163 AGA63164 AGA63165 AGA63167 AGA63171 AGA63172 AGA63176 AGA63177 AGA63180 AGA63184 AGA63193 AGA63198 AGA63199 AGA63206 AGA63217 AGA63222 AGA63223 AGA63224 AGA63226 AGA63228 AGA63231 AGA63232 AGA63235 AGA63238 AGA63239 AGA63240 AGA63251 AGA63252 AGA63268 AGA63269 AGA63277 AGA63278 AGA63291 AGA63292 AGA63293 AGA63294 AGA63299 AGA63301 AGA63302 AGA63303 AGA63308 AGA63309 AGA63310 AGA63311 AGA63322 AGA63323 AGA63324 AGA63325 AGA63328 AGA63329 AGA63330 AGA63331 AGA63336 AGA63342 AGA63343 AGA63344 AGA63347 AGA63349 AGA63352 AGA63359 AGA63361 AGA63367 AGA63369 AGA63376 AGA63379 AGA63384 AGA63389 AGA63391 AGA63396 AGA63399 AGA63405 AGA63407 AGA63409 AGA63410 AGA63413 AGA63414 AGA63415 AGA63416 AGA63417 AGA63421 AGA63424 AGA63425 AGA63429 AGA63431 AGA63432 AGA63436 AGA63437
RNA Seq Atlas 7157