Homo sapiens Gene: CHD3
Summary
InnateDB Gene IDBG-27053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHD3
Gene Name chromodomain helicase DNA binding protein 3
Synonyms Mi-2a; Mi2-ALPHA; ZFH;
Species Homo sapiens
Ensembl Gene ENSG00000170004
Encoded Proteins
chromodomain helicase DNA binding protein 3
chromodomain helicase DNA binding protein 3
chromodomain helicase DNA binding protein 3
chromodomain helicase DNA binding protein 3
chromodomain helicase DNA binding protein 3
chromodomain helicase DNA binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7884806-7912760
Strand Forward strand
Band p13.1
Transcripts
ENST00000380358 ENSP00000369716
ENST00000330494 ENSP00000332628
ENST00000358181 ENSP00000350907
ENST00000452447 ENSP00000405861
ENST00000439235 ENSP00000395252
ENST00000449744 ENSP00000411959
ENST00000479080
ENST00000470531 ENSP00000467547
ENST00000466233
ENST00000473376
ENST00000481999
ENST00000573936 ENSP00000459321
ENST00000574022
ENST00000572750
ENST00000571249 ENSP00000458861
ENST00000570758
ENST00000572579
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 190 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 190 [view]
Protein-Protein 189 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006325 chromatin organization
GO:0006333 chromatin assembly or disassembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007051 spindle organization
GO:0008152 metabolic process
GO:0016568 chromatin modification
GO:0032508 DNA duplex unwinding
GO:0051297 centrosome organization
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016581 NuRD complex
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase I Transcription pathway
RNA Polymerase I Promoter Clearance pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
RNA Polymerase I Transcription Initiation pathway
Chromatin modifying enzymes pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
Mechanisms of transcriptional repression by dna methylation [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class I
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1107
UniGene Hs.25601 Hs.706339
RefSeq NM_001005271 NM_001005273 NM_005852 XM_005256429 XM_005256431 XM_006721428 XM_006721429 XM_006721430
HUGO HGNC:1918
OMIM 602120
CCDS CCDS32553 CCDS32554 CCDS32555
HPRD 09071
IMGT
EMBL
GenPept
RNA Seq Atlas 1107