Homo sapiens Gene: TYK2
Summary
InnateDB Gene IDBG-27182.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYK2
Gene Name tyrosine kinase 2
Synonyms IMD35; JTK1;
Species Homo sapiens
Ensembl Gene ENSG00000105397
Encoded Proteins
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
tyrosine kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TYK2 is directly involved in IFN-alpha signalling for the induction and translocation of Daxx nuclear protein, which may result in B lymphocyte growth arrest and/or apoptosis.
TYK2 modulates the relationship between immunity and metabolism where it is essential for the full LPS response, its function mainly being required for baseline expression and not LPS-induced upregulation of IFN-inducible genes, as well as its critical role in the downregulation of metabolic genes upon immune challenge, in particular genes involved in lipid metabolism.
TYK2 functions at the molecular interface between innate immunity and cellular metabolism and is involved in the regulation of lipid and carbohydrate metabolism in macrophages stimulated with poly(I:C). (Demonstrated in mouse)
TYK2 is necessary for SOCS1-mediated suppression of Type I IFN signalling. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tyk2 functions at the molecular interface between innate immunity and cellular metabolism and is involved in the regulation of lipid and carbohydrate metabolism in macrophages stimulated with poly(I:C).
[Mus musculus] Tyk2 is necessary for Socs1-mediated suppression of Type I IFN signalling.
Entrez Gene
Summary This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10350529-10380676
Strand Reverse strand
Band p13.2
Transcripts
ENST00000264818 ENSP00000264818
ENST00000525976 ENSP00000434831
ENST00000530220
ENST00000524462 ENSP00000433203
ENST00000525621 ENSP00000431885
ENST00000530560 ENSP00000465291
ENST00000529422
ENST00000524470
ENST00000527481 ENSP00000466340
ENST00000529739 ENSP00000436155
ENST00000529412
ENST00000534228
ENST00000529370 ENSP00000432728
ENST00000533334 ENSP00000432320
ENST00000531620
ENST00000525220 ENSP00000434931
ENST00000529317
ENST00000525824 ENSP00000467288
ENST00000531836 ENSP00000436175
ENST00000530829 ENSP00000436826
ENST00000592137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 56 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005131 growth hormone receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031702 type 1 angiotensin receptor binding
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
IL3 pathway
IL4 pathway
IL6 pathway
IL9 pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
SHC-related events pathway
MyD88 dependent cascade initiated on endosome pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
ERK2 activation pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Interferon alpha/beta signaling pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
SHC-related events triggered by IGF1R pathway
Signaling by SCF-KIT pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Frs2-mediated activation pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Interleukin-6 signaling pathway
Regulation of IFNA signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
MAP kinase activation in TLR cascade pathway
IRS-mediated signalling pathway
ERK1 activation pathway
SHC1 events in EGFR signaling pathway
SHC-mediated signalling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Interleukin-2 signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
SHC1 events in ERBB2 signaling pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
Prolonged ERK activation events pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Signaling by FGFR pathway
Signalling to RAS pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
TRIF-mediated TLR3/TLR4 signaling pathway
ERK activation pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Disease pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
DAP12 interactions pathway
KEGG
Osteoclast differentiation pathway
Jak-STAT signaling pathway pathway
Toxoplasmosis pathway
Hepatitis C pathway
INOH
IL-23 signaling pathway
IFN alpha signaling pathway
IL-10 signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
IL-12 signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
No2-dependent il-12 pathway in nk cells [Biocarta view]
Ifn alpha signaling pathway [Biocarta view]
Il12 and stat4 dependent signaling pathway in th1 development [Biocarta view]
Stat3 signaling pathway [Biocarta view]
Il22 soluble receptor signaling pathway [Biocarta view]
PID NCI
IL27-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by PTP1B
IL23-mediated signaling events
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.75516
RefSeq NM_003331
HUGO
OMIM
CCDS CCDS12236
HPRD 01490
IMGT
EMBL
GenPept
RNA Seq Atlas