Homo sapiens Gene: MYC
Summary
InnateDB Gene IDBG-35442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYC
Gene Name v-myc myelocytomatosis viral oncogene homolog (avian)
Synonyms bHLHe39; c-Myc; MRTL; MYCC;
Species Homo sapiens
Ensembl Gene ENSG00000136997
Encoded Proteins
v-myc myelocytomatosis viral oncogene homolog (avian)
v-myc myelocytomatosis viral oncogene homolog (avian)
v-myc myelocytomatosis viral oncogene homolog (avian)
v-myc myelocytomatosis viral oncogene homolog (avian)
v-myc myelocytomatosis viral oncogene homolog (avian)
v-myc avian myelocytomatosis viral oncogene homolog
v-myc avian myelocytomatosis viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Pituitary hormone prolactin (Prl) constrains tumor-promoting liver inflammation by inhibiting Map3k1-dependent activation of Myc at the level of the trafasome.
Entrez Gene
Summary The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt\'s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:127735434-127741434
Strand Forward strand
Band q24.21
Transcripts
ENST00000377970 ENSP00000367207
ENST00000259523 ENSP00000259523
ENST00000517291 ENSP00000429441
ENST00000524013 ENSP00000430235
ENST00000520751 ENSP00000430226
ENST00000621592 ENSP00000478887
ENST00000613283 ENSP00000479618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1433 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 1433 [view]
Protein-Protein 596 [view]
Protein-DNA 732 [view]
Protein-RNA 1 [view]
DNA-DNA 104 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0032403 protein complex binding
GO:0046983 protein dimerization activity
GO:0070491 repressing transcription factor binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0006112 energy reserve metabolic process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006879 cellular iron ion homeostasis
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010332 response to gamma radiation
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0015671 oxygen transport
GO:0032204 regulation of telomere maintenance
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034644 cellular response to UV
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0045087 innate immune response
GO:0045656 negative regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051276 chromosome organization
GO:0051782 negative regulation of cell division
GO:0060070 canonical Wnt signaling pathway
GO:0070848 response to growth factor
GO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001022 positive regulation of response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TGF_beta_Receptor pathway
Prolactin pathway
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
Signaling by NOTCH1 in Cancer pathway
S Phase pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
G1/S Transition pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Cyclin E associated events during G1/S transition pathway
TCF dependent signaling in response to WNT pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by NOTCH1 pathway
Cell Cycle, Mitotic pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Loss of Function of TGFBR1 in Cancer pathway
formation of the beta-catenin:TCF transactivating complex pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Gene Expression pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Cell cycle pathway
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Jak-STAT signaling pathway pathway
Pathways in cancer pathway
Colorectal cancer pathway
Endometrial cancer pathway
Thyroid cancer pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Inhibition of cellular proliferation by gleevec [Biocarta view]
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Overview of telomerase protein component gene htert transcriptional regulation [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Telomeres telomerase cellular aging and immortality [Biocarta view]
Ctcf: first multivalent nuclear factor [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Wnt signaling pathway [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
PID NCI
CD40/CD40L signaling
Ceramide signaling pathway
IL2-mediated signaling events
Validated nuclear estrogen receptor alpha network
Presenilin action in Notch and Wnt signaling
Validated targets of C-MYC transcriptional repression
Validated targets of C-MYC transcriptional activation
LKB1 signaling events
Regulation of nuclear beta catenin signaling and target gene transcription
AP-1 transcription factor network
p73 transcription factor network
C-MYB transcription factor network
E2F transcription factor network
C-MYC pathway
Regulation of nuclear SMAD2/3 signaling
IL2 signaling events mediated by STAT5
FOXM1 transcription factor network
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
IL6-mediated signaling events
Regulation of Telomerase
Notch signaling pathway
Cross-References
SwissProt
TrEMBL E5RGD7
UniProt Splice Variant
Entrez Gene 4609
UniGene Hs.202453 Hs.596284
RefSeq NM_002467
HUGO HGNC:7553
OMIM 190080
CCDS CCDS6359
HPRD 01818
IMGT
EMBL AC103819
GenPept
RNA Seq Atlas 4609