Homo sapiens Gene: SP1
InnateDB Gene IDBG-36616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SP1
Gene Name Sp1 transcription factor
Species Homo sapiens
Ensembl Gene ENSG00000185591
Encoded Proteins
Sp1 transcription factor
Sp1 transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53380176-53416446
Strand Forward strand
Band q13.13
ENST00000327443 ENSP00000329357
ENST00000426431 ENSP00000404263
ENST00000551969 ENSP00000457804
ENST00000548560 ENSP00000458133
Number of Interactions This gene and/or its encoded proteins are associated with 357 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 362 [view]
Protein-Protein 304 [view]
Protein-DNA 53 [view]
Protein-RNA 1 [view]
DNA-DNA 4 [view]
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0035326 enhancer binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0071837 HMG box domain binding
Biological Process
GO:0001503 ossification
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0030219 megakaryocyte differentiation
GO:0030324 lung development
GO:0043353 enucleate erythrocyte differentiation
GO:0043923 positive regulation by host of viral transcription
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048706 embryonic skeletal system development
GO:0060136 embryonic process involved in female pregnancy
GO:0060216 definitive hemopoiesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
AndrogenReceptor pathway
EGFR1 pathway
TGF_beta_Receptor pathway
Leptin pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Cellular responses to stress pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Oncogene Induced Senescence pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
PPARA activates gene expression pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cellular Senescence pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
TGFBR1 KD Mutants in Cancer pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Metabolism pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
TGF-beta signaling pathway pathway
Huntington's disease pathway
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Overview of telomerase rna component gene hterc transcriptional regulation [Biocarta view]
Overview of telomerase protein component gene htert transcriptional regulation [Biocarta view]
Human cytomegalovirus and map kinase pathways [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
FOXA2 and FOXA3 transcription factor networks
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Direct p53 effectors
Validated targets of C-MYC transcriptional repression
AP-1 transcription factor network
HIF-2-alpha transcription factor network
p73 transcription factor network
C-MYB transcription factor network
E2F transcription factor network
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling
HIF-1-alpha transcription factor network
IL2 signaling events mediated by STAT5
Validated transcriptional targets of TAp63 isoforms
FOXM1 transcription factor network
FOXA1 transcription factor network
Regulation of Telomerase
UniProt Splice Variant
Entrez Gene 6667
UniGene Hs.614020 Hs.620754 Hs.625559 Hs.649191
RefSeq NM_001251825 NM_003109 NM_138473 XM_006719570 XM_006719571
OMIM 189906
HPRD 01796
EMBL AC068889 AC073611
RNA Seq Atlas 6667