Homo sapiens Gene: CSNK2A1
Summary
InnateDB Gene IDBG-37787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSNK2A1
Gene Name casein kinase 2, alpha 1 polypeptide
Synonyms CK2A1; CKII; CSNK2A3;
Species Homo sapiens
Ensembl Gene ENSG00000101266
Encoded Proteins
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012] Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:473591-543821
Strand Reverse strand
Band p13
Transcripts
ENST00000217244 ENSP00000217244
ENST00000349736 ENSP00000339247
ENST00000400227 ENSP00000383086
ENST00000400217 ENSP00000383076
ENST00000460062 ENSP00000477147
ENST00000619801 ENSP00000481572
ENST00000609606
ENST00000608066 ENSP00000476486
ENST00000609525 ENSP00000476547
ENST00000608490
ENST00000619188 ENSP00000479630
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 440 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 440 [view]
Protein-Protein 433 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0047485 protein N-terminus binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0008284 positive regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030307 positive regulation of cell growth
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0048511 rhythmic process
GO:0061077 chaperone-mediated protein folding
GO:0071174 mitotic spindle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0031519 PcG protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TNFalpha pathway
Leptin pathway
REACTOME
Developmental Biology pathway
WNT mediated activation of DVL pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Axon guidance pathway
Signal Transduction pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Condensation of Prometaphase Chromosomes pathway
M Phase pathway
TCF dependent signaling in response to WNT pathway
L1CAM interactions pathway
Signal transduction by L1 pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Adherens junction pathway
Tight junction pathway
INOH
PID BIOCARTA
Segmentation clock [Biocarta view]
Lissencephaly gene (lis1) in neuronal migration and development [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Bcr signaling pathway [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Tpo signaling pathway [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Alpha-synuclein signaling
Presenilin action in Notch and Wnt signaling
BCR signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-alpha signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001895 NM_177559 NM_177560
HUGO
OMIM
CCDS CCDS13003 CCDS13004
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas