Mus musculus Gene: Cd86
Summary
InnateDB Gene IDBG-55323.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Cd86
Gene Name T-lymphocyte activation antigen CD86
Synonyms B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1; Ly-58; Ly58; MB7; MB7-2; TS/A-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000022901
Encoded Proteins
T-lymphocyte activation antigen CD86
T-lymphocyte activation antigen CD86
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:36603869-36666081
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000089620 ENSMUSP00000087047
ENSMUST00000135280 ENSMUSP00000117756
ENSMUST00000145506
ENSMUST00000154485
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002376 immune system process
GO:0034138 toll-like receptor 3 signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042113 B cell activation
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
CD28 co-stimulation pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling pathway
PIP3 activates AKT signaling pathway
Intracellular signaling by second messengers pathway
CD28 dependent PI3K/Akt signaling pathway
Costimulation by the CD28 family pathway
CTLA4 inhibitory signaling pathway
Immune System pathway
Signal Transduction pathway
Adaptive Immune System pathway
Negative regulation of the PI3K/AKT network pathway
CD28 dependent Vav1 pathway pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Toll-like receptor signaling pathway pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Kaposi's sarcoma-associated herpesvirus infection pathway
Transcriptional misregulation in cancer pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Rheumatoid arthritis pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D3Z363
UniProt Splice Variant
Entrez Gene 12524
UniGene
RefSeq NM_019388 XM_006521741 XM_011245812
OMIM
CCDS CCDS28155
HPRD
IMGT
MGI ID MGI:101773
MGI Symbol Cd86
EMBL AC117662
GenPept
RNA Seq Atlas 12524