Mus musculus Gene: Il33
InnateDB Gene IDBG-56051.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Il33
Gene Name Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266)
Synonyms 9230117N10Rik; Il-33; Il1f11; NF-HEV;
Species Mus musculus
Ensembl Gene ENSMUSG00000024810
Encoded Proteins
Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266)
Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266)
Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266)
Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266)
Interleukin-33 Interleukin-33(102-266) Interleukin-33(109-266)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Il33 is produced in alveolar macrophages that have been infected with Influenza A virus. The Il33-Il13 signalling axis is required for airway hyper-reactivity in asthma.
Innate lymphoid cells responding to Il33 mediate airway hyperreactivity independently of adaptive immunity.
IL33 predominantly elicits group 2 innate lymphoid cells (ILC2) responses, and IL25 simultaneously elicits phenotypically and functionally distinct ILC2 and multipotent progenitor type 2 cell populations at multiple tissue sites.
Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
Il33 prevents the development of experimental cerebral malaria by orchestrating a protective immune response via type-2 innate lymphoid cells, M2 macrophages and regulatory T cells.
Cigarette smoke decreases Il1rl1 expression on group 2 innate lymphoid cells while elevating Il1rl1 expression on macrophages and natural killer cells, thus altering Il33 responsiveness within the lung to infection.
Group 2 innate lymphoid cell (ILC2)-intrinsic Il33 signalling and Icosl expression promote regulatory T cell accumulation, whereas the inflammatory cytokine Ifng counter-regulates these effects, in part through direct effects on ILC2s.
Il33-dependent group 2 innate lymphoid cells (ILC2s) signal via Areg-Egfr in damaged epithelia to restore epithelial barrier function and maintain tissue homeostasis.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:29925114-29960718
Strand Forward strand
Band C1
ENSMUST00000025724 ENSMUSP00000025724
ENSMUST00000120388 ENSMUSP00000113829
ENSMUST00000136850 ENSMUSP00000135324
ENSMUST00000144528 ENSMUSP00000122319
ENSMUST00000177518 ENSMUSP00000135854
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0002281 macrophage activation involved in immune response
GO:0002282 microglial cell activation involved in immune response
GO:0002686 negative regulation of leukocyte migration
GO:0002826 negative regulation of T-helper 1 type immune response
GO:0002830 positive regulation of type 2 immune response
GO:0006351 transcription, DNA-templated
GO:0010469 regulation of receptor activity
GO:0010628 positive regulation of gene expression
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032689 negative regulation of interferon-gamma production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0032755 positive regulation of interleukin-6 production
GO:0043032 positive regulation of macrophage activation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050729 positive regulation of inflammatory response
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051025 negative regulation of immunoglobulin secretion
GO:0051607 defense response to virus
GO:0061518 microglial cell proliferation
GO:0090197 positive regulation of chemokine secretion
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030133 transport vesicle
GO:0031410 cytoplasmic vesicle
No orthologs found for this gene
Metabolism of proteins pathway
Deubiquitination pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling pathway
PIP3 activates AKT signaling pathway
Intracellular signaling by second messengers pathway
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Post-translational protein modification pathway
Ub-specific processing proteases pathway
Immune System pathway
Interleukin-33 signaling pathway
Signal Transduction pathway
Interleukin-1 family signaling pathway
Negative regulation of the PI3K/AKT network pathway
Cytokine-cytokine receptor interaction pathway
Necroptosis pathway
Cytosolic DNA-sensing pathway pathway
Influenza A pathway
UniProt Splice Variant
Entrez Gene
RefSeq NM_001164724 NM_133775 XM_006527463 XM_011247399
MGI Symbol
RNA Seq Atlas