Mus musculus Gene: Il17a
Summary
InnateDB Gene IDBG-56617.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Il17a
Gene Name Interleukin-17A
Synonyms Ctla-8; Ctla8; IL-17; IL-17A; Il17;
Species Mus musculus
Ensembl Gene ENSMUSG00000025929
Encoded Proteins
Interleukin-17A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Il17a signalling enhances the mRNA stability of chemokine Cxcl1 through Traf3ip2, Traf2-Traf5 and the RNA-binding protein Srsf1.
Il17a is significantly upregulated in both S. pyogenes inoculated and mock inoculated mice, indicating that the cytokine production can be triggered by inoculation trauma alone.
IL17A inhibits the release of IL23 during pulmonary inflammation and serves as part of negative feedback loop to control antibacterial immunity.
Il17a is an intrinsic regulator in coordinating neutrophil and macrophage antimicrobial activity to provide protection against acute pneumonic plague.
In mouse model of leukocyte adhesion deficiency type I disease, defective neutrophil recruitment is associated with dysregulated local overproduction of IL17, which drives inflammatory periodontal bone loss.
Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
Il17a is rapidly produced during lung injury and significantly contributes to early immunopathogenesis, a process that is orchestrated largely by a distinct population of pulmonary type 3 innate lymphoid cells.
Entrez Gene
Summary This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:20730905-20734496
Strand Forward strand
Band A4
Transcripts
ENSMUST00000027061 ENSMUSP00000027061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 6 [view]
Protein-DNA 18 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0006954 inflammatory response
GO:0010469 regulation of receptor activity
GO:0032747 positive regulation of interleukin-23 production
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050832 defense response to fungus
GO:0071347 cellular response to interleukin-1
GO:0072537 fibroblast activation
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:2000778 positive regulation of interleukin-6 secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Interleukin-17 signaling pathway
Immune System pathway
KEGG
Cytokine-cytokine receptor interaction pathway
IL-17 signaling pathway pathway
Th17 cell differentiation pathway
Inflammatory bowel disease (IBD) pathway
Rheumatoid arthritis pathway
INOH
GPCR signaling-cholera toxin-.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q62386
TrEMBL Q544E6
UniProt Splice Variant
Entrez Gene 16171
UniGene
RefSeq NM_010552
OMIM
CCDS CCDS14842
HPRD
IMGT
MGI ID MGI:107364
MGI Symbol Il17a
EMBL AK040420 BC119303 BC119309 CH466536 U35108 U43088
GenPept AAA93253 AAB05222 AAI19304 AAI19310 BAC30590 EDL14378
RNA Seq Atlas 16171