|Mus musculus Gene: Il17a|
|Last Modified||2018-06-05 [Report errors or provide feedback]|
|Synonyms||Ctla-8; Ctla8; IL-17; IL-17A; Il17;|
|Useful resources||Stemformatics EHFPI ImmGen|
Il17a signalling enhances the mRNA stability of chemokine Cxcl1 through Traf3ip2, Traf2-Traf5 and the RNA-binding protein Srsf1.
Il17a is significantly upregulated in both S. pyogenes inoculated and mock inoculated mice, indicating that the cytokine production can be triggered by inoculation trauma alone.
IL17A inhibits the release of IL23 during pulmonary inflammation and serves as part of negative feedback loop to control antibacterial immunity.
Il17a is an intrinsic regulator in coordinating neutrophil and macrophage antimicrobial activity to provide protection against acute pneumonic plague.
In mouse model of leukocyte adhesion deficiency type I disease, defective neutrophil recruitment is associated with dysregulated local overproduction of IL17, which drives inflammatory periodontal bone loss.
Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
Il17a is rapidly produced during lung injury and significantly contributes to early immunopathogenesis, a process that is orchestrated largely by a distinct population of pulmonary type 3 innate lymphoid cells.
This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]
|Genomic Location||Chromosome 1:20730905-20734496|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
|No orthologs found for this gene|
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Interleukin-17 signaling pathway
Immune System pathway
Cytokine-cytokine receptor interaction pathway
IL-17 signaling pathway pathway
Th17 cell differentiation pathway
Inflammatory bowel disease (IBD) pathway
Rheumatoid arthritis pathway
GPCR signaling-cholera toxin-.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
|UniProt Splice Variant|
|EMBL||AK040420 BC119303 BC119309 CH466536 U35108 U43088|
|GenPept||AAA93253 AAB05222 AAI19304 AAI19310 BAC30590 EDL14378|
|RNA Seq Atlas||16171|