Mus musculus Gene: Hc
Summary
InnateDB Gene IDBG-57171.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Hc
Gene Name hemolytic complement
Synonyms C5; C5a; He; Hfib2;
Species Mus musculus
Ensembl Gene ENSMUSG00000026874
Encoded Proteins
hemolytic complement
hemolytic complement
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.
Entrez Gene
Summary This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:34983331-35061438
Strand Reverse strand
Band B
Transcripts
ENSMUST00000028233 ENSMUSP00000028233
ENSMUST00000125549
ENSMUST00000151628
ENSMUST00000156049
ENSMUST00000156412 ENSMUSP00000144345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0002376 immune system process
GO:0006954 inflammatory response
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010760 negative regulation of macrophage chemotaxis
GO:0010951 negative regulation of endopeptidase activity
GO:0019835 cytolysis
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Innate Immune System pathway
Terminal pathway of complement pathway
Class A/1 (Rhodopsin-like receptors) pathway
Complement cascade pathway
GPCR ligand binding pathway
Activation of C3 and C5 pathway
Immune System pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
Regulation of Complement cascade pathway
GPCR downstream signalling pathway
KEGG
Complement and coagulation cascades pathway
Prion diseases pathway
Pertussis pathway
Staphylococcus aureus infection pathway
Herpes simplex infection pathway
Systemic lupus erythematosus pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL A0A0J9YUU3
UniProt Splice Variant
Entrez Gene 15139
UniGene
RefSeq NM_010406 XM_017315669
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:96031
MGI Symbol Hc
EMBL
GenPept
RNA Seq Atlas 15139