Mus musculus Gene: Il1a
Summary
InnateDB Gene IDBG-57450.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Il1a
Gene Name Interleukin-1 alpha
Synonyms Il-1a;
Species Mus musculus
Ensembl Gene ENSMUSG00000027399
Encoded Proteins
Interleukin-1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.
In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.
Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:129299610-129309972
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028882 ENSMUSP00000028882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 3 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005507 copper ion binding
Biological Process
GO:0001660 fever generation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008285 negative regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0032755 positive regulation of interleukin-6 production
GO:0034605 cellular response to heat
GO:0035234 ectopic germ cell programmed cell death
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046688 response to copper ion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0051781 positive regulation of cell division
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000391 positive regulation of neutrophil extravasation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Interleukin-1 processing pathway
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Interleukin-1 signaling pathway
Immune System pathway
Interleukin-1 family signaling pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Necroptosis pathway
Cellular senescence pathway
Osteoclast differentiation pathway
Hematopoietic cell lineage pathway
Non-alcoholic fatty liver disease (NAFLD) pathway
AGE-RAGE signaling pathway in diabetic complications pathway
Type I diabetes mellitus pathway
Prion diseases pathway
Salmonella infection pathway
Pertussis pathway
Leishmaniasis pathway
Tuberculosis pathway
Measles pathway
Influenza A pathway
Inflammatory bowel disease (IBD) pathway
Rheumatoid arthritis pathway
Graft-versus-host disease pathway
Fluid shear stress and atherosclerosis pathway
INOH
GPCR signaling-cholera toxin-.owl pathway
IL-1 JNK.owl pathway
IL-1 p38.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
IL-1 NFkB.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P01582
TrEMBL Q3U0Y6
UniProt Splice Variant
Entrez Gene 16175
UniGene
RefSeq NM_010554 XM_006498793 XM_006498794
OMIM
CCDS CCDS16725
HPRD
IMGT
MGI ID MGI:96542
MGI Symbol Il1a
EMBL AF010237 AK156449 AY902318 BC003727 CH466519 X01450
GenPept AAC28999 AAH03727 AAX90603 BAE33715 CAA25682 EDL28237
RNA Seq Atlas 16175