Mus musculus Gene: Clock
Summary
InnateDB Gene IDBG-58544.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Clock
Gene Name Circadian locomoter output cycles protein kaput
Synonyms 5330400M04Rik; KAT13D;
Species Mus musculus
Ensembl Gene ENSMUSG00000029238
Encoded Proteins
Circadian locomoter output cycles protein kaput
Circadian locomoter output cycles protein kaput
Circadian locomoter output cycles protein kaput
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76209868-76304792
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000075159 ENSMUSP00000074656
ENSMUST00000200957
ENSMUST00000201052
ENSMUST00000202122 ENSMUSP00000144022
ENSMUST00000202651 ENSMUSP00000143939
ENSMUST00000202857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003700 DNA binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0016573 histone acetylation
GO:0032922 circadian regulation of gene expression
GO:0042634 regulation of hair cycle
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:0050729 positive regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051775 response to redox state
GO:0071479 cellular response to ionizing radiation
GO:2000074 regulation of type B pancreatic cell development
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033391 chromatoid body
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Circadian rhythm pathway
Dopaminergic synapse pathway
Herpes simplex infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001289826 NM_001305222 NM_007715 XM_011249402 XM_017320648 XM_017320649 XM_017320650 XM_017320651
OMIM
CCDS CCDS19360 CCDS84889
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas