Mus musculus Gene: Nlrp3
Summary
InnateDB Gene IDBG-60460.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Nlrp3
Gene Name NACHT, LRR and PYD domains-containing protein 3
Synonyms AGTAVPRL; AII/AVP; Cias1; FCAS; FCU; Mmig1; MWS; NALP3; Pypaf1;
Species Mus musculus
Ensembl Gene ENSMUSG00000032691
Encoded Proteins
NACHT, LRR and PYD domains-containing protein 3
NACHT, LRR and PYD domains-containing protein 3
NACHT, LRR and PYD domains-containing protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Nlrp3 mediated immune responses can be activated by RNA and mice lacking Nlrp3, or other inflammasome components, exhibit increased mortality and a reduced immune response after influenza virus exposure.
Nlrp3(-/-) mice exhibit increased morbidity after infection with a pathogenic influenza A virus correlating with decreased neutrophil and monocyte recruitment and reduced IL-1beta, IL-18, TNF-alpha, IL-6, KC, MIP2, and IFN-alpha production.
Nlrp3 is directly activated by certain antibiotics and plays an important role in the antibiotic-mediated secretion of Il1b. In the case of polymyxin B, Nlrp3 was also required for the neutrophil influx into the peritoneal cavity.
Nlrp3 inflammasome is essential for host defence against influenza and other RNA viruses (i.e. EMCV, VSV).
Nlrp3 recruits adaptor protein Pycard and Casp1 to form an Nlrp3 inflammasome complex in response to Varicella-Zoster Virus (VZV) infection.
Nlrp3 is a component of the inflammasome and is required for inflammation in acute pancreatitis.
Nlrp3 is necessary to illicit Il1b response specific to viable, but not heat-killed, E. coli infections.
Nlrp3 inflammasome plays a role in innate immune responses against mucosal Candida infection. Nlrp3 limits the severity of infection when present in either the hematopoietic or stromal compartments.
Nlrp3/Pycard inflammasome activation following human respiratory syncytial virus infection is dependent on the activation of Tlr2/Myd88/NF-kB and reactive oxygen species/potassium efflux. (Demonstrated in human)
MIR223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1beta production.
Potassium efflux is a common trigger of NLRP3 Inflammasome activation by bacterial toxins and particulate matter
Mitochondrial membrane potential is required for the association of Nlrp3 and Mfn2. Mfns2 is required for the activation of Nlrp3 inflammasomes.
3, 4-methylenedioxy-β-nitrostyrene is a potent and specific inhibitor of the NLRP3 inflammasome.
Both Nlrp3 and Nlrp1a are important regulators of Toxoplasma proliferation and that IL18 signaling is required to mediate host resistance to acute toxoplasmosis.
Group B streptococcus induces Il1b, and activates the NLRP3 inflammasome by a mechanism that requires hemolysin-mediated lysosomal leakage, which enhances the interaction of bacterial RNA with NLRP3.
Activation of the Nlrp3 inflammasome is detrimental during leishmaniasis. Mice lacking the inflammasome components Nlrp3, Pycard, Casp1 exhibit defective Il1b and Il18 production at the infection site and are resistant to cutaneous Leishmania major infection.
Nlrp3 is a novel molecular target for melatonin which requires Rora to blunt the NFkB/ NLRP3 connection during sepsis.
Uropathogenic Escherichia coli protein TcpC attenuates activation of the Nlrp3 inflammasome by binding both Nlrp3 and Casp1.
Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.
Nlrp3 and Casp2 are required for endoplasmic reticulum stress-induced inflammation.
Impairment of the mitochondrial electron transport chain by rotenone primes Nlrp3 inflammasome activation upon costimulation with ATP.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:59541568-59566956
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000079476 ENSMUSP00000078440
ENSMUST00000101148 ENSMUSP00000098707
ENSMUST00000149126 ENSMUSP00000114231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002374 cytokine secretion involved in immune response
GO:0002376 immune system process
GO:0002674 negative regulation of acute inflammatory response
GO:0002830 positive regulation of type 2 immune response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032611 interleukin-1 beta production
GO:0032621 interleukin-18 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546 NLRP3 inflammasome complex assembly
GO:0045087 innate immune response (InnateDB)
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050701 interleukin-1 secretion
GO:0050713 negative regulation of interleukin-1 beta secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
GO:0071224 cellular response to peptidoglycan
GO:2000321 positive regulation of T-helper 17 cell differentiation
GO:2000553 positive regulation of T-helper 2 cell cytokine production
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0061702 inflammasome complex
GO:0072559 NLRP3 inflammasome complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Inflammasomes pathway
Deubiquitination pathway
Innate Immune System pathway
The NLRP3 inflammasome pathway
Post-translational protein modification pathway
Metalloprotease DUBs pathway
Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
KEGG
Necroptosis pathway
NOD-like receptor signaling pathway pathway
C-type lectin receptor signaling pathway pathway
Pertussis pathway
Influenza A pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q5SXI6
UniProt Splice Variant
Entrez Gene 216799
UniGene
RefSeq NM_145827 XM_006532857 XM_006532858
OMIM
CCDS CCDS24771
HPRD
IMGT
MGI ID MGI:2653833
MGI Symbol Nlrp3
EMBL AL592522
GenPept
RNA Seq Atlas 216799