Mus musculus Gene: Il25
Summary
InnateDB Gene IDBG-63409.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Il25
Gene Name interleukin 25
Synonyms IL-17e; Il17e;
Species Mus musculus
Ensembl Gene ENSMUSG00000040770
Encoded Proteins
interleukin 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:54932695-54935837
Strand Forward strand
Band C2
Transcripts
ENSMUST00000037863 ENSMUSP00000039641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0030380 interleukin-17E receptor binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0006954 inflammatory response
GO:0009620 response to fungus
GO:0009624 response to nematode
GO:0010469 regulation of receptor activity
GO:0030222 eosinophil differentiation
GO:0032616 interleukin-13 production
GO:0032634 interleukin-5 production
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
IL-17 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_080729 XM_017315843
OMIM
CCDS CCDS36926
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas