Homo sapiens Gene: AP2A1
Summary
InnateDB Gene IDBG-63459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP2A1
Gene Name adaptor-related protein complex 2, alpha 1 subunit
Synonyms ADTAA; AP2-ALPHA; CLAPA1;
Species Homo sapiens
Ensembl Gene ENSG00000196961
Encoded Proteins
adaptor-related protein complex 2, alpha 1 subunit
adaptor-related protein complex 2, alpha 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49766968-49807113
Strand Forward strand
Band q13.33
Transcripts
ENST00000359032 ENSP00000351926
ENST00000354293 ENSP00000346246
ENST00000601356
ENST00000600199
ENST00000593788
ENST00000594838
ENST00000597774 ENSP00000472492
ENST00000600466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 66 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008565 protein transporter activity
GO:0019901 protein kinase binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006895 Golgi to endosome transport
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050690 regulation of defense response to virus by virus
GO:1900126 negative regulation of hyaluronan biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030117 membrane coat
GO:0030122 AP-2 adaptor complex
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030131 clathrin adaptor complex
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
PCP/CE pathway pathway
MHC class II antigen presentation pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by EGFR pathway
Axon guidance pathway
Signal Transduction pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Nef Mediated CD8 Down-regulation pathway
Recycling pathway of L1 pathway
Adaptive Immune System pathway
Immune System pathway
Trafficking of AMPA receptors pathway
NGF signalling via TRKA from the plasma membrane pathway
Retrograde neurotrophin signalling pathway
Transmission across Chemical Synapses pathway
L1CAM interactions pathway
Nef Mediated CD4 Down-regulation pathway
EPH-ephrin mediated repulsion of cells pathway
HIV Infection pathway
EGFR downregulation pathway
EPH-Ephrin signaling pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
Trafficking of GluR2-containing AMPA receptors pathway
Disease pathway
KEGG
Endocytosis pathway
Huntington's disease pathway
INOH
PID BIOCARTA
Ss-arrestins in gpcr desensitization [Biocarta view]
Endocytotic role of ndk phosphins and dynamin [Biocarta view]
PID NCI
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467125
RefSeq NM_014203 NM_130787
HUGO
OMIM
CCDS CCDS46148 CCDS46149
HPRD 03016
IMGT
EMBL
GenPept
RNA Seq Atlas