Homo sapiens Gene: PSMC5
Summary
InnateDB Gene IDBG-63742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMC5
Gene Name proteasome (prosome, macropain) 26S subunit, ATPase, 5
Synonyms p45; p45/SUG; S8; SUG-1; SUG1; TBP10; TRIP1;
Species Homo sapiens
Ensembl Gene ENSG00000087191
Encoded Proteins
proteasome (prosome, macropain) 26S subunit, ATPase, 5
proteasome (prosome, macropain) 26S subunit, ATPase, 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63827152-63832026
Strand Forward strand
Band q23.3
Transcripts
ENST00000310144 ENSP00000310572
ENST00000375812 ENSP00000364970
ENST00000582420
ENST00000580265
ENST00000583283
ENST00000581764
ENST00000585242 ENSP00000463107
ENST00000584320 ENSP00000462098
ENST00000579031
ENST00000581842 ENSP00000463549
ENST00000579147
ENST00000584880 ENSP00000464347
ENST00000585123 ENSP00000464602
ENST00000584657
ENST00000579708 ENSP00000464405
ENST00000582130 ENSP00000463801
ENST00000578570
ENST00000580063
ENST00000584536 ENSP00000464646
ENST00000580864 ENSP00000462495
ENST00000581882 ENSP00000463938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 203 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 203 [view]
Protein-Protein 199 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATPase activity
GO:0017025 TBP-class protein binding
GO:0017111 nucleoside-triphosphatase activity
GO:0031531 thyrotropin-releasing hormone receptor binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006366 transcription from RNA polymerase II promoter
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008152 metabolic process
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0030163 protein catabolic process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043069 negative regulation of programmed cell death
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0090261 positive regulation of inclusion body assembly
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031410 cytoplasmic vesicle
GO:0031595 nuclear proteasome complex
GO:0031597 cytosolic proteasome complex
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
PCP/CE pathway pathway
truncated APC mutants destabilize the destruction complex pathway
p53-Dependent G1/S DNA damage checkpoint pathway
p53-Independent G1/S DNA damage checkpoint pathway
Processing-defective Hh variants abrogate ligand secretion pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Synthesis of DNA pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Vif-mediated degradation of APOBEC3G pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Stabilization of p53 pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
ER-Phagosome pathway pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
Ubiquitin-dependent degradation of Cyclin D pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Antigen processing-Cross presentation pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Metabolism of amino acids and derivatives pathway
Removal of licensing factors from origins pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of ornithine decarboxylase (ODC) pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
p53-Dependent G1 DNA Damage Response pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Cyclin E associated events during G1/S transition pathway
Hedgehog ligand biogenesis pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Switching of origins to a post-replicative state pathway
Asymmetric localization of PCP proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
M/G1 Transition pathway
degradation of AXIN pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
CDT1 association with the CDC6:ORC:origin complex pathway
p53-Independent DNA Damage Response pathway
G1/S DNA Damage Checkpoints pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
Regulation of DNA replication pathway
Signaling by the B Cell Receptor (BCR) pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Vpu mediated degradation of CD4 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Regulation of Apoptosis pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Proteasome pathway
INOH
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593889
RefSeq NM_001199163 NM_002805 XM_006721980
HUGO
OMIM
CCDS CCDS11645 CCDS56043
HPRD 03400
IMGT
EMBL
GenPept
RNA Seq Atlas