|Homo sapiens Gene: IL1A|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 1, alpha|
|Synonyms||IL-1A; IL1; IL1-ALPHA; IL1F1;|
interleukin 1, alpha
|Useful resources||Stemformatics EHFPI ImmGen|
Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.
IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release
IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
|InnateDB Annotation from Orthologs|
[Mus musculus] Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.
[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
[Mus musculus] NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.
[Mus musculus] Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 2:112773915-112784590|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Ortholog supports species divergence
Not yet available
Ortholog supports species divergence
Cellular responses to stress pathway
Cytokine Signaling in Immune system pathway
Interleukin-1 processing pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Osteoclast differentiation pathway
Hematopoietic cell lineage pathway
Type I diabetes mellitus pathway
Prion diseases pathway
Graft-versus-host disease pathway
GPCR signaling pathway
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
Nf-kb signaling pathway [Biocarta view]
Stress induction of hsp regulation [Biocarta view]
Signal transduction through il1r [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
Il-10 anti-inflammatory signaling pathway [Biocarta view]
IL1-mediated signaling events
a6b1 and a6b4 Integrin signaling
Validated transcriptional targets of deltaNp63 isoforms
|UniProt Splice Variant|
|EMBL||AC112235 AF536338 AK314850 BC013142 BN000002 BT007014 CH471217 CR457414 M15329 M28983 X02531 X02851 X03833 X56086|
|GenPept||AAA59133 AAA59134 AAH13142 AAM96189 AAP35660 AAX93054 BAG37367 CAA26371 CAA26604 CAA27448 CAA39566 CAD29871 CAG33695 EAW73604|
|RNA Seq Atlas||3552|