Homo sapiens Gene: KNG1
Summary
InnateDB Gene IDBG-69059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KNG1
Gene Name kininogen 1
Synonyms BDK; BK; KNG;
Species Homo sapiens
Ensembl Gene ENSG00000113889
Encoded Proteins
kininogen 1
kininogen 1
kininogen 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:186717276-186743954
Strand Forward strand
Band q27.3
Transcripts
ENST00000287611 ENSP00000287611
ENST00000265023 ENSP00000265023
ENST00000447445 ENSP00000396025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
Biological Process
GO:0002576 platelet degranulation
GO:0006939 smooth muscle contraction
GO:0006954 inflammatory response
GO:0007162 negative regulation of cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0010951 negative regulation of endopeptidase activity
GO:0030168 platelet activation
GO:0030195 negative regulation of blood coagulation
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0042311 vasodilation
GO:0043065 positive regulation of apoptotic process
GO:0045861 negative regulation of proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Peptide ligand-binding receptors pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Intrinsic Pathway pathway
Response to elevated platelet cytosolic Ca2+ pathway
GPCR ligand binding pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Corticosteroids and cardioprotection [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.732792 Hs.77741
RefSeq NM_000893 NM_001102416 NM_001166451
HUGO
OMIM
CCDS CCDS3281 CCDS43183 CCDS54695
HPRD 01970
IMGT
EMBL
GenPept
RNA Seq Atlas