|Mus musculus Gene: Mir146|
|Last Modified||2018-06-05 [Report errors or provide feedback]|
|Gene Name||microRNA 146|
|Useful resources||Stemformatics EHFPI ImmGen|
Mir146 directly targets Relb to modulate the amplitude of monocyte responses to inflammatory challenges.
Mir146 is a mechanosensitive miRNA that modulates mechanotransduction and pressure-induced inflammation in small airway epithelium. (Demonstrated in human)
Nod2 driven inflammation is regulated by nitric oxide responsive Mir146 that facilitates activation of sonic hedgehog (SHH) signalling by targeting Numb expression.
T-cell-intrinsic Mir155 is required for type-2 immunity, in part through regulation of S1pr1, whereas T-cell-intrinsic Mir146 is required to prevent overt Th1/Th17 skewing.
Mir146 attenuates sepsis-induced cardiac dysfunction by preventing NFκB activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of Irak1 and Traf6 in both cardiomyocytes and inflammatory monocytic cells.
Mir146 has a role in constraining intestinal barrier function, a process that alters gut homeostasis and increases susceptibility to dextran sodium sulphate-induced colitis.
|Summary||Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.|
|Genomic Location||Chromosome 11:43374397-43374461|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
|UniProt Splice Variant|
|RNA Seq Atlas|