Homo sapiens Gene: ANXA1
Summary
InnateDB Gene IDBG-71054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANXA1
Gene Name annexin A1
Synonyms ANX1; LPC1;
Species Homo sapiens
Ensembl Gene ENSG00000135046
Encoded Proteins
annexin A1
annexin A1
annexin A1
annexin A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ANXA1 is cleaved by CAPN1 to generate a N-terminally truncated form of ANXA1 shown to be anti-inflammatory and able to activate ERK. This C-terminal ANXA1 peptide functions by increasing ICAM1 clustering around adherent neutrophils to anchor them to the endothelium and promote transmigration through the transcellular route.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Anxa1-/- mice are more susceptible to Mycobacterium tuberculosis infection as evidenced by a transient increase in pulmonary bacterial burden, exacerbated and disorganized granulomatous inflammation and impaired ability of Anxa1-/- dendritic cells to activate naïve T cells.
Entrez Gene
Summary Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:73151757-73170393
Strand Forward strand
Band q21.13
Transcripts
ENST00000257497 ENSP00000257497
ENST00000376911 ENSP00000366109
ENST00000456643 ENSP00000412489
ENST00000415424 ENSP00000414013
ENST00000468639
ENST00000495713
ENST00000489109
ENST00000491192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 87 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0003727 single-stranded RNA binding
GO:0004386 helicase activity
GO:0004859 phospholipase inhibitor activity
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0030674 protein binding, bridging
GO:0033676 double-stranded DNA-dependent ATPase activity
GO:0036310 annealing helicase activity
GO:0042803 protein homodimerization activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000733 DNA strand renaturation
GO:0001780 neutrophil homeostasis
GO:0006200 ATP catabolic process
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0009725 response to hormone
GO:0010165 response to X-ray
GO:0014070 response to organic cyclic compound
GO:0018149 peptide cross-linking
GO:0030073 insulin secretion
GO:0030216 keratinocyte differentiation
GO:0030850 prostate gland development
GO:0031018 endocrine pancreas development
GO:0031340 positive regulation of vesicle fusion
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031960 response to corticosteroid
GO:0032355 response to estradiol
GO:0032508 DNA duplex unwinding
GO:0033031 positive regulation of neutrophil apoptotic process
GO:0036292 DNA rewinding
GO:0042063 gliogenesis
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0043434 response to peptide hormone
GO:0045087 innate immune response (InnateDB)
GO:0046632 alpha-beta T cell differentiation
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0051384 response to glucocorticoid
GO:0060206 estrous cycle phase
GO:0070301 cellular response to hydrogen peroxide
GO:0070365 hepatocyte differentiation
GO:0070459 prolactin secretion
GO:0070555 response to interleukin-1
GO:0071385 cellular response to glucocorticoid stimulus
GO:0097350 neutrophil clearance
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900138 negative regulation of phospholipase A2 activity
GO:2000483 negative regulation of interleukin-8 secretion
Cellular Component
GO:0001533 cornified envelope
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0009986 cell surface
GO:0016323 basolateral plasma membrane
GO:0031966 mitochondrial membrane
GO:0042383 sarcolemma
GO:0042629 mast cell granule
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TSH pathway
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Formyl peptide receptors bind formyl peptides and many other ligands pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
INOH
PID BIOCARTA
Corticosteroids and cardioprotection [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.494173 Hs.595342
RefSeq NM_000700
HUGO
OMIM
CCDS CCDS6645
HPRD 01060
IMGT
EMBL
GenPept
RNA Seq Atlas