Mus musculus Gene: C5ar2
Summary
InnateDB Gene IDBG-72156.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol C5ar2
Gene Name complement component 5a receptor 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000074361
Encoded Proteins
complement component 5a receptor 2
complement component 5a receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Gpr77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of Gpr77 results in the amplification of complement pro-inflammatory responses.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16234585-16244154
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000098792 ENSMUSP00000096389
ENSMUST00000171425 ENSMUSP00000133056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004878 complement component C5a receptor activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032720 negative regulation of tumor necrosis factor production
GO:0038178 complement component C5a signaling pathway
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090024 negative regulation of neutrophil chemotaxis
GO:1900165 negative regulation of interleukin-6 secretion
GO:2000482 regulation of interleukin-8 secretion
Cellular Component
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045177 apical part of cell
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL E9PVQ2 E9QQ21
UniProt Splice Variant
Entrez Gene 319430
UniGene
RefSeq NM_001146005 NM_176912
OMIM
CCDS CCDS52036 CCDS52037
HPRD
IMGT
MGI ID MGI:2442013
MGI Symbol C5ar2
EMBL AC156630
GenPept
RNA Seq Atlas 319430