Homo sapiens Gene: HSPA8
Summary
InnateDB Gene IDBG-74847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPA8
Gene Name heat shock 70kDa protein 8
Synonyms HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71;
Species Homo sapiens
Ensembl Gene ENSG00000109971
Encoded Proteins
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
heat shock 70kDa protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:123057489-123063230
Strand Reverse strand
Band q24.1
Transcripts
ENST00000227378 ENSP00000227378
ENST00000453788 ENSP00000404372
ENST00000532636 ENSP00000437125
ENST00000533540 ENSP00000437189
ENST00000534624 ENSP00000432083
ENST00000532091
ENST00000534319 ENSP00000433316
ENST00000526110 ENSP00000433584
ENST00000524552 ENSP00000435908
ENST00000526686 ENSP00000435019
ENST00000533238
ENST00000526862
ENST00000527983
ENST00000528292 ENSP00000432884
ENST00000532780
ENST00000525463 ENSP00000436762
ENST00000532167
ENST00000525624 ENSP00000435154
ENST00000534567 ENSP00000431641
ENST00000527387 ENSP00000436183
ENST00000532182 ENSP00000434415
ENST00000524590 ENSP00000434565
ENST00000530391 ENSP00000434851
ENST00000531063
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 371 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 371 [view]
Protein-Protein 367 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0023026 MHC class II protein complex binding
GO:0031072 heat shock protein binding
GO:0042623 ATPase activity, coupled
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006986 response to unfolded protein
GO:0007049 cell cycle
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007411 axon guidance
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0042026 protein refolding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0051726 regulation of cell cycle
GO:0061024 membrane organization
GO:0072318 clathrin coat disassembly
GO:1902904 negative regulation of fibril organization
Cellular Component
GO:0000974 Prp19 complex
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0042470 melanosome
GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
RANKL pathway
TSH pathway
REACTOME
Cellular responses to stress pathway
Developmental Biology pathway
trans-Golgi Network Vesicle Budding pathway
Regulation of HSF1-mediated heat shock response pathway
CHL1 interactions pathway
Neuronal System pathway
Attenuation phase pathway
Axon guidance pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
GABA synthesis, release, reuptake and degradation pathway
Clathrin derived vesicle budding pathway
HSF1-dependent transactivation pathway
Golgi Associated Vesicle Biogenesis pathway
Cellular response to heat stress pathway
Transmission across Chemical Synapses pathway
L1CAM interactions pathway
Neurotransmitter Release Cycle pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Lysosome Vesicle Biogenesis pathway
mRNA Splicing pathway
Gene Expression pathway
Membrane Trafficking pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
MAPK signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Endocytosis pathway
Antigen processing and presentation pathway
Toxoplasmosis pathway
INOH
PID BIOCARTA
PID NCI
C-MYB transcription factor network
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL E9PN25
UniProt Splice Variant
Entrez Gene 85390
UniGene
RefSeq NM_006597 NM_153201 XM_006718831
HUGO HGNC:5241
OMIM 600816
CCDS CCDS44754 CCDS8440
HPRD 07205
IMGT
EMBL AP000926
GenPept
RNA Seq Atlas 3312 85389 85390