AAP: Allergy and Asthma Portal

Homo sapiens Gene: PRKRA

Summary

InnateDB Gene

IDBG-76030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKRA

Gene Name

protein kinase, interferon-inducible double stranded RNA dependent activator

Synonyms

DYT16; PACT; RAX;

Species

Homo sapiens

Ensembl Gene

ENSG00000180228

Encoded Proteins

IDBP-76032

protein kinase, interferon-inducible double stranded RNA dependent activator

IDBP-387793

protein kinase, interferon-inducible double stranded RNA dependent activator

IDBP-387795

protein kinase, interferon-inducible double stranded RNA dependent activator

IDBP-387797

protein kinase, interferon-inducible double stranded RNA dependent activator

IDBP-387798

protein kinase, interferon-inducible double stranded RNA dependent activator

IDBP-483631

protein kinase, interferon-inducible double stranded RNA dependent activator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25784705

The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.

PMID 26608320

A defective interfering RNA isolated from the Hu-191 vaccine strain of measles virus is sensed by PRKRA and DDX58 to initiate an innate antiviral response.

PMID 26454002

DDX3X participates in antiviral innate immunity by controlling translation of PRKRA.

Entrez Gene

Summary

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:178431414-178451512

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000325748	ENSP00000318176
ENST00000432031	ENSP00000393883
ENST00000424699	ENSP00000408029
ENST00000448279	ENSP00000388455
ENST00000457633	ENSP00000408668
ENST00000490501
ENST00000487082	ENSP00000430604
ENST00000474793
ENST00000470200
ENST00000460433
ENST00000466165
ENST00000463882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.

Experimentally validated
Total	73 [view]
Protein-Protein	69 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0016301	kinase activity
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0010467	gene expression
GO:0030422	production of siRNA involved in RNA interference
GO:0034599	cellular response to oxidative stress
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0043085	positive regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0048705	skeletal system morphogenesis
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000002731

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000001096

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_12417

MicroRNA (miRNA) biogenesis pathway

REACT_118560

Small interfering RNA (siRNA) biogenesis pathway

REACT_71

Gene Expression pathway

REACT_12472

Regulatory RNA pathways pathway

KEGG

INOH

PID BIOCARTA

PID NCI

ceramide_pathway

Ceramide signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001139517 NM_001139518 NM_003690

HUGO

OMIM

CCDS

CCDS2279 CCDS46460 CCDS46461

HPRD

04573

IMGT

EMBL

GenPept

RNA Seq Atlas