Homo sapiens Gene: SRPK1
Summary
InnateDB Gene IDBG-84414.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRPK1
Gene Name SRSF protein kinase 1
Synonyms SFRSK1;
Species Homo sapiens
Ensembl Gene ENSG00000096063
Encoded Proteins
SRSF protein kinase 1
SRSF protein kinase 1
SRSF protein kinase 1
SRSF protein kinase 1
SRSF protein kinase 1
SRSF protein kinase 1
SRSF protein kinase 1
SRSF protein kinase 1
SRSF protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:35832966-35921342
Strand Reverse strand
Band p21.31
Transcripts
ENST00000361690 ENSP00000354674
ENST00000373825 ENSP00000362931
ENST00000373822 ENSP00000362928
ENST00000373821
ENST00000346162
ENST00000423325 ENSP00000391069
ENST00000505885
ENST00000507292 ENSP00000422886
ENST00000502969
ENST00000510290 ENSP00000424170
ENST00000508473 ENSP00000425172
ENST00000512445 ENSP00000424068
ENST00000513367
ENST00000507909 ENSP00000424323
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 372 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 372 [view]
Protein-Protein 372 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0008380 RNA splicing
GO:0016032 viral process
GO:0035092 sperm chromatin condensation
GO:0035556 intracellular signal transduction
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0048024 regulation of mRNA splicing, via spliceosome
GO:0050684 regulation of mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL H0Y932
UniProt Splice Variant
Entrez Gene 6732
UniGene Hs.443861 Hs.611831
RefSeq NM_003137
HUGO HGNC:11305
OMIM 601939
CCDS CCDS47415
HPRD 15992
IMGT
EMBL Z99128
GenPept
RNA Seq Atlas 6732