Homo sapiens Gene: JUN
Summary
InnateDB Gene IDBG-99221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JUN
Gene Name jun proto-oncogene
Synonyms AP-1; AP1; c-Jun;
Species Homo sapiens
Ensembl Gene ENSG00000177606
Encoded Proteins
jun proto-oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
JUN interacts with NFATC2 to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
Entrez Gene
Summary This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:58780788-58784327
Strand Reverse strand
Band p32.1
Transcripts
ENST00000371222 ENSP00000360266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 519 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 521 [view]
Protein-Protein 288 [view]
Protein-DNA 227 [view]
Protein-RNA 1 [view]
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0035497 cAMP response element binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0044822 poly(A) RNA binding
GO:0070412 R-SMAD binding
GO:0071837 HMG box domain binding
Biological Process
GO:0001525 angiogenesis
GO:0001774 microglial cell activation
GO:0001836 release of cytochrome c from mitochondria
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003151 outflow tract morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007184 SMAD protein import into nucleus
GO:0007568 aging
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0009987 cellular process
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0030224 monocyte differentiation
GO:0031103 axon regeneration
GO:0031953 negative regulation of protein autophosphorylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035026 leading edge cell differentiation
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0043923 positive regulation by host of viral transcription
GO:0045087 innate immune response (InnateDB)
GO:0045657 positive regulation of monocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051365 cellular response to potassium ion starvation
GO:0051403 stress-activated MAPK cascade
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0051899 membrane depolarization
GO:0060395 SMAD protein signal transduction
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0000228 nuclear chromosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL5 pathway
IL6 pathway
RANKL pathway
Prolactin pathway
REACTOME
Cellular responses to stress pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Pre-NOTCH Expression and Processing pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Innate Immune System pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activation of the AP-1 family of transcription factors pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Pre-NOTCH Transcription and Translation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
FCERI mediated MAPK activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
GnRH signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
INOH
TNFR1 signaling pathway pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Atm signaling pathway [Biocarta view]
The 41bb-dependent immune response [Biocarta view]
The information processing pathway at the ifn beta enhancer [Biocarta view]
Inhibition of cellular proliferation by gleevec [Biocarta view]
Hypoxia-inducible factor in the cardivascular system [Biocarta view]
Toll-like receptor pathway [Biocarta view]
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Tsp-1 induced apoptosis in microvascular endothelial cell [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Bcr signaling pathway [Biocarta view]
Repression of pain sensation by the transcriptional regulator dream [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Agrin in postsynaptic differentiation [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Il12 and stat4 dependent signaling pathway in th1 development [Biocarta view]
Pertussis toxin-insensitive ccr5 signaling in macrophage [Biocarta view]
Signal transduction through il1r [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Mets affect on macrophage differentiation [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Tpo signaling pathway [Biocarta view]
D4gdi signaling pathway [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Erythropoietin mediated neuroprotection through nf-kb [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Nephrin/Neph1 signaling in the kidney podocyte
CD40/CD40L signaling
Calcium signaling in the CD4+ TCR pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Validated transcriptional targets of AP1 family members Fra1 and Fra2
LPA receptor mediated events
Regulation of retinoblastoma protein
IL2-mediated signaling events
Validated nuclear estrogen receptor alpha network
Presenilin action in Notch and Wnt signaling
IL1-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
S1P2 pathway
Direct p53 effectors
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
ErbB1 downstream signaling
ATF-2 transcription factor network
Signaling events mediated by focal adhesion kinase
IL12 signaling mediated by STAT4
Regulation of nuclear beta catenin signaling and target gene transcription
Integrin-linked kinase signaling
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
RAC1 signaling pathway
FGF signaling pathway
Endothelins
BCR signaling pathway
ErbB2/ErbB3 signaling events
JNK signaling in the CD4+ TCR pathway
CDC42 signaling events
Regulation of nuclear SMAD2/3 signaling
HIF-1-alpha transcription factor network
Signaling mediated by p38-alpha and p38-beta
Signaling events regulated by Ret tyrosine kinase
RhoA signaling pathway
Regulation of Androgen receptor activity
Fc-epsilon receptor I signaling in mast cells
FOXA1 transcription factor network
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
IL6-mediated signaling events
Regulation of Telomerase
Osteopontin-mediated events
Cross-References
SwissProt P05412
TrEMBL
UniProt Splice Variant
Entrez Gene 3725
UniGene Hs.525704 Hs.696684
RefSeq NM_002228
HUGO HGNC:6204
OMIM 165160
CCDS CCDS610
HPRD 01302
IMGT
EMBL AL136985 AY217548 BC002646 BC006175 BC009874 BC068522 BT019759 J04111
GenPept AAA59197 AAH06175 AAH09874 AAH68522 AAO22993 AAV38564 CAC10201
RNA Seq Atlas 3725