Allergy and Asthma Curated Genes

Aside from annotating allergy/asthma relevant molecular interaction networks, the AAP curation team has also established a project to annotate which genes have a published role in allergy and/or asthma induced immune responses. To undertake this annotation, curators employ our curation system to associate relevant genes with publications which provide evidence for that gene having a role in allergy and/or asthma immune responses. Along with the link to the relevant publication(s), the curators provide a one or two line summary of the role similar to Entrez GeneRIFs. It should be noted that it is not our intention to comprehensively annotate all the roles of a given gene. You can download all AAP curated genes with their annotations as an Excel sheet.
The current version includes a subset of 800 human or mouse genes.

Review the latest annotations: View all
Gene name Annotations Added
NOD1 (Homo sapiens) PubMed 23524653: Bacterial infection-mediated activation of NOD1 and NOD2 triggers allergic asthma via the activation of eosinophils interacting with bronchial epithelial cells at inflammatory airway
PubMed 24661094: NOD1 priming of dendritic cells promotes a T-cell helper 2 polarization profile which involves the production of CCL17 in allergic patients.
2014-04-02
ACAA1 (Homo sapiens) PubMed 22151743: Increased endotoxin exposure (by quartile) showed protective effects for asthma in individuals with at least one copy of a minor allele in the ACAA1 gene.
2014-04-02
CCL17 (Homo sapiens) PubMed 24661094: NOD1 priming of dendritic cells promotes a T-cell helper 2 polarization profile which involves the production of CCL17 in allergic patients.
2014-04-02
IRAK3 (Homo sapiens) PubMed 24074582: IRAK3 plays a role in human rhinovirus (HRV) infection where its over-expression promotes lung epithelial HRV-16 replication and autophagy.
2014-04-02
ITGB5 (Homo sapiens) PubMed 22025551: Bronchoconstriction promotes airway remodeling via ITGAV/ITGB5-integrin mediated TGFB1 activation
PubMed 23984888: A genome-wide association study of airway hyperresponsiveness (AHR) revealed that variants within the ITGB5 and AGFG1 genes are associated with severity of airway responsiveness and are involved in modulating AHR.
2014-04-02
IRF4 (Homo sapiens) PubMed 22515488: IRF4 may play a role in the systemic inflammation of allergic asthma patients by facilitating the differentiation of Th2 and Th17 cells at the transcriptional level
PubMed 21919915: Increased expression of IRF4 in allergen-challenged CD4(+) cells from patients with intermittent allergic rhinitis leads to activation of a complex transcriptional program, including Th2 cytokines
PubMed 24074333: Polymorphisms in the IRF4 gene are associated with recurrent bronchitis and asthma.
2014-04-02
AGFG1 (Homo sapiens) PubMed 23984888: A genome-wide association study of airway hyperresponsiveness (AHR) revealed that variants within the ITGB5 and AGFG1 genes are associated with severity of airway responsiveness and are involved in modulating AHR.
2014-04-02
Il17a (Mus musculus) PubMed 24336249: Obesity-associated airway hyperreactivity is independent of adaptive immunity and is facilitated by inflammation mediated by Nlrp3, Il1b and Il17a??producing type 3 innate lymphoid cells.
2014-04-02
Gpr77 (Mus musculus) PubMed 24043888: Gpr77 (C5L2) plays a role as a negative regulator of anaphylatoxin activity by suppressing C5a-C5aR-mediated responses in allergic contact sensitivity.
PubMed 24043888: Gpr77 (C5L2) plays a role as a negative regulator of anaphylatoxin activity by suppressing Hc (C5a)-C5ar1-mediated responses in allergic contact sensitivity.
2014-04-02
C5ar1 (Mus musculus) PubMed 24043888: Gpr77 (C5L2) plays a role as a negative regulator of anaphylatoxin activity by suppressing C5a-C5aR-mediated responses in allergic contact sensitivity.
PubMed 24043888: Gpr77 (C5L2) plays a role as a negative regulator of anaphylatoxin activity by suppressing Hc (C5a)-C5ar1-mediated responses in allergic contact sensitivity.
2014-04-02
Il33 (Mus musculus) PubMed 24663677: Uric acid (UA) promotes secretion of Il33 by airway epithelial cells in vitro, and administration of UA into the airways of naive animals induces extracellular release of Il33, followed by both innate and adaptive type 2 immune responses in vivo.
2014-04-02
Cd86 (Mus musculus) PubMed 24487979: Il25 promotes the accumulation of co-stimulatory molecules of Cd80 and Cd86 on dendritic cells and induces the differentiation of prime naive CD4+ T cells to become proinflammatory Th2 cells in ovalbumin-induced airway inflammation.
2014-04-02
Cd80 (Mus musculus) PubMed 24487979: Il25 promotes the accumulation of co-stimulatory molecules of Cd80 and Cd86 on dendritic cells and induces the differentiation of prime naive CD4+ T cells to become proinflammatory Th2 cells in ovalbumin-induced airway inflammation.
2014-04-02
Il25 (Mus musculus) PubMed 24487979: Il25 promotes the accumulation of co-stimulatory molecules of Cd80 and Cd86 on dendritic cells and induces the differentiation of prime naive CD4+ T cells to become proinflammatory Th2 cells in ovalbumin-induced airway inflammation.
2014-04-02
Hc (Mus musculus) PubMed 24043888: Gpr77 (C5L2) plays a role as a negative regulator of anaphylatoxin activity by suppressing Hc (C5a)-C5ar1-mediated responses in allergic contact sensitivity.
2014-04-02
Clock (Mus musculus) PubMed 24060274: The mast cell-intrinsic Clock, entrained by humoral factors from the adrenal gland, primarily contributes to the temporal regulation of IgE/mast cell-mediated allergic reactions.
2014-04-02
Nlrp3 (Mus musculus) PubMed 24336249: Obesity-associated airway hyperreactivity is independent of adaptive immunity and is facilitated by inflammation mediated by Nlrp3, Il1b and Il17a??producing type 3 innate lymphoid cells.
2014-04-02
Tlr7 (Mus musculus) PubMed 24041926: Tlr7 dampens the allergic airway reactivity and local inflammation, whereas Tlr9 causes airway hyperresponsiveness and increased cellular response.
2014-04-02
Tlr9 (Mus musculus) PubMed 24041926: Tlr7 dampens the allergic airway reactivity and local inflammation, whereas Tlr9 causes airway hyperresponsiveness and increased cellular response.
2014-04-02
Il1b (Mus musculus) PubMed 24336249: Obesity-associated airway hyperreactivity is independent of adaptive immunity and is facilitated by inflammation mediated by Nlrp3, Il1b and Il17a??producing type 3 innate lymphoid cells.
2014-04-02