Allergy and Asthma Curated Interactions

As a proof-of-principle of the value of annotating the "allergy interactome" (i.e. the collection of molecular interactions of relevance to allergy), the InnateDB team was funded in 2011 by AllerGen (strategic project grant) to establish a small curation team over several weeks to interrogate the literature for molecular interactions of relevance to allergy/asthma. After a general review of databases, their pathway coverage, and AllerGen priorities, the curation team focused on molecular interactions involving component molecules of the KEGG Asthma Pathway and a number of genes implicated in genome-wide associations of asthma. Over this period the team annotated 6754 human, mouse and rat molecular interactions of relevance to allergy/asthma that are published in the biomedical literature but were not previously annotated in either InnateDB or any of the top 5 other public molecular interaction databases.

The current version includes a subset of 6754 manually curated interactions involving 800 human or mouse genes. An extra 139 interactions were shown in species currently not part of InnateDB.

Review the latest annotations: View all
Gene name Curated interaction(s) Added
MYC (Homo sapiens) MYC physically associates with RUVBL1 AAP-2063543
PubMed: 11839798
2018-02-10
HIF1A (Homo sapiens) SP1 physically associates with HIF1A AAP-2063538
PubMed: 15780936
2018-01-20
MYC (Homo sapiens) SP1 physically associates with MYC AAP-2063537
PubMed: 15780936 , 15944709
2018-01-20
SP1 (Homo sapiens) SP1 physically associates with MYC AAP-2063537
PubMed: 15780936
2018-01-20
HIF1A (Homo sapiens) HIF1A physically associates with MSH2 promoter in hypoxic HCT116 cells AAP-2063534
PubMed: 15780936
2018-01-13
TP53 (Homo sapiens) TP53 physically associates with MSH2 promoter AAP-2063528
PubMed: 15780936
2018-01-13
MYC (Homo sapiens) MYC physically associates with MSH6 promoter AAP-2063526
PubMed: 15780936
2018-01-13
SP1 (Homo sapiens) SP1 physically associates with CDKN1A promoter AAP-2063531
PubMed: 15780936
2018-01-13
CDKN1A (Homo sapiens) MYC physically associates with CDKN1A promoter AAP-2063527
PubMed: 15780936
2018-01-13
JUN (Homo sapiens) FBXW7 physically associates with JUN AAP-2063522
PubMed: 16023596
2018-01-13
JUN (Homo sapiens) FBXW7 physcially associates with JUN AAP-2063521
PubMed: 16023596
2017-12-23
MYC (Homo sapiens) E2F1 directly interacts with MYC P2 promoter AAP-2063502
PubMed: 7892279
2017-05-28
E2F1 (Homo sapiens) E2F1 directly interacts with MYC P2 promoter AAP-2063502
PubMed: 7892279
2017-05-28
CHD3 (Homo sapiens) ZNF219 physically associates with CHD3 AAP-2063161
PubMed: 26186194
2016-12-19
TYK2 (Homo sapiens) ZNF333 physically associates with TYK2 AAP-2063105
PubMed: 26186194
2016-12-19
CSNK2A1 (Homo sapiens) ZNF707 physically associates with CSNK2A1 AAP-2062949
PubMed: 26186194
2016-12-19
PPP2CA (Homo sapiens) ZNF114 physically associates with PPP2CA AAP-2063176
PubMed: 26186194
2016-12-19
GYS1 (Homo sapiens) ZFP41 physically associates with GYS1 AAP-2063220
PubMed: 26186194
2016-12-19
AP2A1 (Homo sapiens) ZBTB46 physically associates with AP2A1 AAP-2063324
PubMed: 26186194
2016-12-19
FTSJ3 (Homo sapiens) ZC3H3 physically associates with FTSJ3 AAP-2063306
PubMed: 26186194
2016-12-19