Allergy and Asthma Curated Interactions

As a proof-of-principle of the value of annotating the "allergy interactome" (i.e. the collection of molecular interactions of relevance to allergy), the InnateDB team was funded in 2011 by AllerGen (strategic project grant) to establish a small curation team over several weeks to interrogate the literature for molecular interactions of relevance to allergy/asthma. After a general review of databases, their pathway coverage, and AllerGen priorities, the curation team focused on molecular interactions involving component molecules of the KEGG Asthma Pathway and a number of genes implicated in genome-wide associations of asthma. Over this period the team annotated 6725 human, mouse and rat molecular interactions of relevance to allergy/asthma that are published in the biomedical literature but were not previously annotated in either InnateDB or any of the top 5 other public molecular interaction databases.

The current version includes a subset of 6725 manually curated interactions involving 800 human or mouse genes. An extra 139 interactions were shown in species currently not part of InnateDB.

Review the latest annotations: View all
Gene name Curated interaction(s) Added
MYC (Homo sapiens) E2F1 directly interacts with MYC P2 promoter AAP-2063502
PubMed: 7892279
2017-05-28
E2F1 (Homo sapiens) E2F1 directly interacts with MYC P2 promoter AAP-2063502
PubMed: 7892279
2017-05-28
CHD3 (Homo sapiens) ZNF219 physically associates with CHD3 AAP-2063161
PubMed: 26186194
2016-12-19
TYK2 (Homo sapiens) ZNF333 physically associates with TYK2 AAP-2063105
PubMed: 26186194
2016-12-19
CSNK2A1 (Homo sapiens) ZNF707 physically associates with CSNK2A1 AAP-2062949
PubMed: 26186194
2016-12-19
PPP2CA (Homo sapiens) ZNF114 physically associates with PPP2CA AAP-2063176
PubMed: 26186194
2016-12-19
GYS1 (Homo sapiens) ZFP41 physically associates with GYS1 AAP-2063220
PubMed: 26186194
2016-12-19
AP2A1 (Homo sapiens) ZBTB46 physically associates with AP2A1 AAP-2063324
PubMed: 26186194
2016-12-19
FTSJ3 (Homo sapiens) ZC3H3 physically associates with FTSJ3 AAP-2063306
PubMed: 26186194
2016-12-19
PSMC5 (Homo sapiens) ZFAND2B physically associates with PSMC5 AAP-2063239
PubMed: 26186194
2016-12-19
KNG1 (Homo sapiens) ZNF562 physically associates with KNG1 AAP-2062979
PubMed: 26186194
2016-12-19
HSPA8 (Homo sapiens) ZNF434 physically associates with HSPA8 AAP-2063052
PubMed: 26186194
2016-12-19
HDAC1 (Homo sapiens) ZNF219 physically associates with HDAC1 AAP-2063156
PubMed: 26186194
2016-12-19
NOTCH2 (Homo sapiens) ZFP41 physically associates with NOTCH2 AAP-2063205
PubMed: 26186194
2016-12-19
ANXA1 (Homo sapiens) ZSCAN20 physically associates with ANXA1 AAP-2062816
PubMed: 26186194
2016-12-12
MZF1 (Homo sapiens) ZSCAN1 physically associates with MZF1 AAP-2062826
PubMed: 26186194
2016-12-12
SRPK1 (Homo sapiens) ZRSR2 physically associates with SRPK1 AAP-2062836
PubMed: 26186194
2016-12-12
UBQLN4 (Homo sapiens) BPIFA1 (PLUNC) physically associates with UBQLN4 (A1Up) AAP-2062702
PubMed: 16713569
2016-11-21
SNX6 (Homo sapiens) SNX6 mRNA physically associates with ELAVL1 AAP-2062335
PubMed: 19322201
2016-11-12
YWHAG (Homo sapiens) YWHAG mRNA physically associates with ELAVL1 (HuR) AAP-2062423
PubMed: 19322201
2016-11-12