Homo sapiens Gene: ITGB5
Summary
InnateDB Gene IDBG-106735.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol ITGB5
Gene Name integrin subunit beta 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000082781
Encoded Proteins
integrin subunit beta 5
integrin subunit beta 5
integrin subunit beta 5
integrin subunit beta 5
integrin subunit beta 5
integrin subunit beta 5
integrin subunit beta 5
integrin subunit beta 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:124761948-124901418
Strand Reverse strand
Band q21.2
Transcripts
ENST00000296181 ENSP00000296181
ENST00000460797
ENST00000461306
ENST00000465464 ENSP00000418079
ENST00000474838
ENST00000476988
ENST00000481591 ENSP00000420814
ENST00000483168 ENSP00000419198
ENST00000488466 ENSP00000477446
ENST00000496703 ENSP00000418367
ENST00000608107 ENSP00000476655
ENST00000608657 ENSP00000477230
ENST00000608945
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 70 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006936 muscle contraction
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0016032 viral process
GO:0030198 extracellular matrix organization
GO:0035987 endodermal cell differentiation
GO:0043149 stress fiber assembly
GO:0046718 viral entry into host cell
GO:0090136 epithelial cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034684 integrin alphav-beta5 complex
GO:0043235 receptor complex
GO:0045335 phagocytic vesicle
GO:0070062 extracellular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
Leptin pathway
REACTOME
Integrin cell surface interactions pathway
ECM proteoglycans pathway
Syndecan interactions pathway
Non-integrin membrane-ECM interactions pathway
Elastic fibre formation pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Antigen processing-Cross presentation pathway
Muscle contraction pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Adaptive Immune System pathway
Molecules associated with elastic fibres pathway
Smooth Muscle Contraction pathway
Extracellular matrix organization pathway
KEGG
Phagosome pathway
PI3K-Akt signaling pathway pathway
Focal adhesion pathway
ECM-receptor interaction pathway
Regulation of actin cytoskeleton pathway
Human papillomavirus infection pathway
Proteoglycans in cancer pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy (DCM) pathway
INOH
Integrin.owl pathway
PID BIOCARTA
PID NCI
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Regulation of nuclear SMAD2/3 signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Signaling events mediated by focal adhesion kinase
Integrin family cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001354764 NM_001354765 NM_002213 XM_005247436 XM_006713630 XM_017006351 XM_017006352 XM_017006353 XM_017006354 XM_017006355
HUGO
OMIM
CCDS CCDS3030
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas