Mus musculus Gene: Gpr77
Summary
InnateDB Gene IDBG-146283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpr77
Gene Name G protein-coupled receptor 77
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000074361
Encoded Proteins
G protein-coupled receptor 77
G protein-coupled receptor 77
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Gpr77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of Gpr77 results in the amplification of complement pro-inflammatory responses.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] GPR77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of GPR77 results in the amplification of complement pro-inflammatory responses. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134830:
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16234585-16244154
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000098792 ENSMUSP00000096389
ENSMUST00000171425 ENSMUSP00000133056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004944 C5a anaphylatoxin receptor activity
GO:0005515 protein binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032720 negative regulation of tumor necrosis factor production
GO:0045087 innate immune response (InnateDB)
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090024 negative regulation of neutrophil chemotaxis
GO:1900165 negative regulation of interleukin-6 secretion
GO:2000482 regulation of interleukin-8 secretion
Cellular Component
GO:0009925 basal plasma membrane
GO:0016021 integral component of membrane
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR ligand binding pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8BW93
TrEMBL E9PVQ2
UniProt Splice Variant
Entrez Gene 319430
UniGene Mm.239570
RefSeq NM_176912 XM_006540051 XM_006540056 NM_001146005 XM_006540053 XM_006540057
OMIM
CCDS CCDS52037 CCDS52036
HPRD
IMGT
MGI ID MGI:2442013
MGI Symbol C5ar2
EMBL AC156630 AK053187 AK160050 BC137941 BC145834
GenPept AAI37942 AAI45835 BAC35303 BAE35590
RNA Seq Atlas 319430