Mus musculus Gene: Cd80
Summary
InnateDB Gene IDBG-160288.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd80
Gene Name CD80 antigen
Synonyms B71; Cd28l; Ly-53; Ly53; MIC17; TSA1;
Species Mus musculus
Ensembl Gene ENSMUSG00000075122
Encoded Proteins
CD80 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121594:
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:38458933-38486933
Strand Forward strand
Band B4
Transcripts
ENSMUST00000099816 ENSMUSP00000097404
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031295 T cell costimulation
GO:0042102 positive regulation of T cell proliferation
GO:0045087 innate immune response
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
CD28 dependent PI3K/Akt signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
CD28 dependent Vav1 pathway pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
CTLA4 inhibitory signaling pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Toll-like receptor signaling pathway pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
CD28 co-stimulation pathway
CD28 dependent Vav1 pathway pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Costimulation by the CD28 family pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
CTLA4 inhibitory signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Toll-like receptor signaling pathway pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
GPCR signaling pathway
CD4 T cell receptor signaling pathway
PID BIOCARTA
The co-stimulatory signal during t-cell activation [Biocarta view]
PID NCI
Cross-References
SwissProt Q00609
TrEMBL Q3U4B5 Q549R2 Q6LD87 Q9JHC3
UniProt Splice Variant
Entrez Gene 12519
UniGene
RefSeq NM_009855 XM_006521737
OMIM
CCDS CCDS28168
HPRD
IMGT
MGI ID MGI:101775
MGI Symbol Cd80
EMBL AF065894 AF065895 AF065896 AJ278965 AK154329 AY278186 BC131959 BC145843 D16220 L12585 L12586 L12587 L12588 L12589 S74540 S74695 S74696 X60958
GenPept AAA37240 AAB32535 AAB32537 AAD25877 AAD25878 AAD25879 AAI31960 AAI45844 AAP57303 BAA03748 BAE32518 CAA43291 CAC34306
RNA Seq Atlas 12519