|Mus musculus Gene: Ifnb1|
|Last Modified||2018-06-05 [Report errors or provide feedback]|
|Gene Name||interferon beta 1, fibroblast|
|Synonyms||Ifb; IFN-beta; IFNB;|
interferon beta 1, fibroblast
|Useful resources||Stemformatics EHFPI ImmGen|
Ifnb1 deficiency results in a partial suppression of the sterol pathway in macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses.
Ifnb1 secretion is greater upon viable E. coli infection in comparison to heat killed E. coli vaccine or LPS. The induction of Ifnb1 is dependent on Ticam1-Irf3 signalling.
Ifnb1 expression pattern during viral infection is a highly stochastic process influenced by cell-to-cell variability in viral induction processes.
Ifnb1 production is fundamental to the efficient control of Listeria monocytogenes during the early innate phase of infection. NK cells treated with Ifnb1 during early infection were able to reduce bacterial titer in the spleen and significantly improve survival of infected mice.
The noncanonical NFκB pathway regulates histone modifications at the Ifnb1 promoter resulting in attenuated recruitment of Rela and histone demethylase, Kdm4a, to the Ifnb1 promoter. This provides a mechanism for regulating the induction of type I interferons .
The innate immune system plays a role in immunogenic tumour recognition. Tumor-cell-derived DNA triggers Ifnb1 production and dendritic cell activation via Tmem173 and Irf3 cytosolic DNA sensing pathways.
Ifnb1 selectively restricts the transcriptional responses mediated by both the TLRs and the NOD-like receptors in Salmonella enterica serovar Typhimurium infection in macrophages.
Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.
|Summary||Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.|
|Genomic Location||Chromosome 4:88522025-88522774|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
|No orthologs found for this gene|
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Regulation of IFNA signaling pathway
Immune System pathway
Cytokine-cytokine receptor interaction pathway
PI3K-Akt signaling pathway pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chagas disease (American trypanosomiasis) pathway
Hepatitis C pathway
Hepatitis B pathway
Influenza A pathway
Human papillomavirus infection pathway
Kaposi's sarcoma-associated herpesvirus infection pathway
Herpes simplex infection pathway
GPCR signaling-cholera toxin-.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
|UniProt Splice Variant|
|EMBL||BC119395 BC119397 CH466527 K00020 X14029 X14455|
|GenPept||AAA37891 AAI19396 AAI19398 CAA32190 CAA32625 EDL30977|
|RNA Seq Atlas||15977|