Homo sapiens Gene: E2F1
Summary
InnateDB Gene IDBG-67214.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F1
Gene Name E2F transcription factor 1
Synonyms E2F-1; RBAP1; RBBP3; RBP3;
Species Homo sapiens
Ensembl Gene ENSG00000101412
Encoded Proteins
E2F transcription factor 1
E2F transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
E2F1 is important for normal inflammatory response to systemic LPS by enhancing the production of IL6 and TNFA in macrophages. (Demonstrated in murine model)
E2F1 directly binds to the promoter of TLR3 to inhibit transcription. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] E2f1 is important for normal inflammatory response to systemic LPS by enhancing the production of Il6 and Tnfa in murine macrophages.
[Mus musculus] E2f1 directly binds to the promoter of Tlr3 to inhibit transcription.
Entrez Gene
Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:33675487-33686404
Strand Reverse strand
Band q11.22
Transcripts
ENST00000343380 ENSP00000345571
ENST00000622594 ENSP00000480001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 599 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 601 [view]
Protein-Protein 176 [view]
Protein-DNA 422 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000080 mitotic G1 phase
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000085 mitotic G2 phase
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0007219 Notch signaling pathway
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628 positive regulation of gene expression
GO:0030900 forebrain development
GO:0043276 anoikis
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048255 mRNA stabilization
GO:0051726 regulation of cell cycle
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1990086 lens fiber cell apoptotic process
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0035189 Rb-E2F complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
G1 Phase pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Activation of NOXA and translocation to mitochondria pathway
Pre-NOTCH Expression and Processing pathway
Mitotic G1-G1/S phases pathway
Cyclin D associated events in G1 pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of PUMA and translocation to mitochondria pathway
Apoptosis pathway
Signal Transduction pathway
G1/S-Specific Transcription pathway
Cell Cycle pathway
Pre-NOTCH Transcription and Translation pathway
Association of licensing factors with the pre-replicative complex pathway
Activation of BH3-only proteins pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
Cellular Senescence pathway
G0 and Early G1 pathway
E2F mediated regulation of DNA replication pathway
Signaling by NOTCH pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Intrinsic Pathway for Apoptosis pathway
Mitotic G2-G2/M phases pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Oxidative Stress Induced Senescence pathway
G2 Phase pathway
Assembly of the pre-replicative complex pathway
KEGG
Cell cycle pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
PID BIOCARTA
Rb tumor suppressor/checkpoint signaling in response to dna damage [Biocarta view]
Cell cycle: g1/s check point [Biocarta view]
E2f1 destruction pathway [Biocarta view]
Cyclin e destruction pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
Mets affect on macrophage differentiation [Biocarta view]
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
P53 signaling pathway [Biocarta view]
Cyclins and cell cycle regulation [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Notch-mediated HES/HEY network
p75(NTR)-mediated signaling
E2F transcription factor network
IL2 signaling events mediated by PI3K
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1869
UniGene
RefSeq NM_005225
HUGO HGNC:3113
OMIM 189971
CCDS CCDS13224
HPRD
IMGT
EMBL AF516106 AL121906 BC050369 BC058902 M96577 S49592 S74230 U47675 U47676 U47677
GenPept AAA35782 AAB24289 AAC50719 AAD14150 AAH50369 AAH58902 AAM47604 CAC08486
RNA Seq Atlas 1869