Homo sapiens Gene: HDAC1
Summary
InnateDB Gene IDBG-95712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC1
Gene Name histone deacetylase 1
Synonyms GON-10; HD1; RPD3; RPD3L1;
Species Homo sapiens
Ensembl Gene ENSG00000116478
Encoded Proteins
histone deacetylase 1
histone deacetylase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
HDAC1 Inhibition decreases IFN-alpha responsiveness whereas its expression augments the IFN-alpha response, demonstrating that it modulates IFN-alpha-induced transcription.
Histone deacetylase 1 (HDAC1) is part of a repressor complex, along with key components that include HDAC2, RE-1 silencing transcription factor (REST), co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.
Entrez Gene
Summary Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:32292086-32333635
Strand Forward strand
Band p35.2
Transcripts
ENST00000373548 ENSP00000362649
ENST00000428704 ENSP00000407859
ENST00000481281
ENST00000463172
ENST00000472928
ENST00000490081
ENST00000482310
ENST00000476391
ENST00000484305
ENST00000471488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 816 experimentally validated interaction(s) in this database.
Experimentally validated
Total 816 [view]
Protein-Protein 674 [view]
Protein-DNA 24 [view]
Protein-RNA 0
DNA-DNA 118 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0031492 nucleosomal DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0033613 activating transcription factor binding
GO:0042826 histone deacetylase binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006476 protein deacetylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0009913 epidermal cell differentiation
GO:0010467 gene expression
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016032 viral process
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0032922 circadian regulation of gene expression
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043044 ATP-dependent chromatin remodeling
GO:0043066 negative regulation of apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0045087 innate immune response (InnateDB)
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060789 hair follicle placode formation
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0043234 protein complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
IL6 pathway
TWEAK pathway
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
truncated APC mutants destabilize the destruction complex pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signalling by NGF pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNA Polymerase I Transcription pathway
Signaling by WNT in cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
Signaling by NOTCH1 in Cancer pathway
p75NTR negatively regulates cell cycle via SC1 pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of beta-catenin by the destruction complex pathway
deactivation of the beta-catenin transactivating complex pathway
Epigenetic regulation of gene expression pathway
p75 NTR receptor-mediated signalling pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
HDACs deacetylate histones pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
G0 and Early G1 pathway
TCF dependent signaling in response to WNT pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
RNA Polymerase I Transcription Initiation pathway
repression of WNT target genes pathway
TGFBR1 KD Mutants in Cancer pathway
Factors involved in megakaryocyte development and platelet production pathway
Chromatin modifying enzymes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Cell Cycle, Mitotic pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
Loss of Function of TGFBR1 in Cancer pathway
formation of the beta-catenin:TCF transactivating complex pathway
TGFBR1 LBD Mutants in Cancer pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Negative epigenetic regulation of rRNA expression pathway
Hemostasis pathway
Signaling by TGF-beta Receptor Complex pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
KEGG
Cell cycle pathway
Notch signaling pathway pathway
Huntington's disease pathway
Pathways in cancer pathway
Chronic myeloid leukemia pathway
INOH
TGF-beta signaling pathway
PID BIOCARTA
The prc2 complex sets long-term gene silencing through modification of histone tails [Biocarta view]
Cell cycle: g1/s check point [Biocarta view]
Downregulated of mta-3 in er-negative breast tumors [Biocarta view]
Mechanisms of transcriptional repression by dna methylation [Biocarta view]
Overview of telomerase protein component gene htert transcriptional regulation [Biocarta view]
Sumoylation by ranbp2 regulates transcriptional repression [Biocarta view]
Control of gene expression by vitamin d receptor [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Regulation of retinoblastoma protein
Validated nuclear estrogen receptor alpha network
Presenilin action in Notch and Wnt signaling
Validated targets of C-MYC transcriptional repression
Signaling events mediated by HDAC Class I
Notch-mediated HES/HEY network
Regulation of nuclear beta catenin signaling and target gene transcription
Glucocorticoid receptor regulatory network
E2F transcription factor network
Retinoic acid receptors-mediated signaling
Regulation of nuclear SMAD2/3 signaling
IL3-mediated signaling events
Sumoylation by RanBP2 regulates transcriptional repression
Hedgehog signaling events mediated by Gli proteins
Regulation of Androgen receptor activity
Regulation of Telomerase
Notch signaling pathway
Cross-References
SwissProt Q13547
TrEMBL F5GXM1 Q6IT96
UniProt Splice Variant
Entrez Gene 3065
UniGene Hs.88556
RefSeq NM_004964
HUGO HGNC:4852
OMIM 601241
CCDS CCDS360
HPRD 03143
IMGT
EMBL AB451430 AL109945 AY627042 BC000301 CH471059 CR541717 D50405 U50079
GenPept AAC50475 AAH00301 AAT44863 BAA08909 BAG70244 CAG46518 EAX07540 EAX07541
RNA Seq Atlas 3065