Homo sapiens Gene: TANK
Summary
InnateDB Gene IDBG-112457.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol TANK
Gene Name TRAF family member associated NFKB activator
Synonyms I-TRAF; ITRAF; TRAF2;
Species Homo sapiens
Ensembl Gene ENSG00000136560
Encoded Proteins
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
TRAF family member associated NFKB activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TANK is involved in interferon responses and is a negative regulator of pro-inflammatory cytokine production induced by TLR signalling.
TANK plays a key role in the cross-talk between the IKK-related and the canonical IKK kinases, a mechanism required to limit the strength of TLR-signalling and prevent autoimmunity. (Demonstrated in mice)
Entrez Gene
Summary The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:161136908-161236221
Strand Forward strand
Band q24.2
Transcripts
ENST00000259075 ENSP00000259075
ENST00000392749 ENSP00000376505
ENST00000402568 ENSP00000384235
ENST00000403609 ENSP00000385983
ENST00000405852 ENSP00000385487
ENST00000406287 ENSP00000384492
ENST00000429217 ENSP00000411041
ENST00000432002 ENSP00000398157
ENST00000432692 ENSP00000412622
ENST00000437623 ENSP00000412556
ENST00000439442 ENSP00000387439
ENST00000440506 ENSP00000399934
ENST00000441987 ENSP00000410259
ENST00000456358 ENSP00000392776
ENST00000457887 ENSP00000388930
ENST00000461338
ENST00000463502
ENST00000468831
ENST00000470324
ENST00000477952
ENST00000483622
ENST00000489393
ENST00000494976
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 120 [view]
Protein-Protein 120 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0035800 deubiquitinase activator activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006974 cellular response to DNA damage stimulus
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0016032 viral process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071479 cellular response to ionizing radiation
GO:1903003 positive regulation of protein deubiquitination
GO:2000158 positive regulation of ubiquitin-specific protease activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 macromolecular complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
TNFalpha pathway
REACTOME
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll-Like Receptors Cascades pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
TICAM1-dependent activation of IRF3/IRF7 pathway
Immune System pathway
TRIF(TICAM1)-mediated TLR4 signaling pathway
Innate Immune System pathway
DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway
MyD88-independent TLR4 cascade pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
TRAF6 mediated IRF7 activation pathway
KEGG
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001199135 NM_004180 NM_133484 XM_005246207 XM_017003093 XM_017003094 XM_017003095 XM_017003096 XM_017003097
HUGO
OMIM
CCDS CCDS2215 CCDS46436
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas